Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.36 |
| ▸ | CDK9 | P50750 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5401787 | 1.00 | KDM5A (0.37) | KDM5ATRPV1CDK9PIK3CDMAP4K1 | |
| SCHEMBL5401784 | 1.00 | KDM5A (0.37) | KDM5ATRPV1CDK9PIK3CDMAP4K1 | |
| SCHEMBL5408206 | 0.90 | MAP4K1 (0.41) | TRPV1MAP4K1 | |
| SCHEMBL5408211 | 0.90 | MAP4K1 (0.41) | TRPV1MAP4K1 | |
| SCHEMBL5408202 | 0.90 | MAP4K1 (0.41) | TRPV1MAP4K1 | |
| SCHEMBL5405688 | 0.89 | CCNA2 (0.43) | KDM5ATRPV1PIK3CDMAP4K1CCNA2 | |
| SCHEMBL5405682 | 0.89 | CCNA2 (0.43) | KDM5ATRPV1PIK3CDMAP4K1CCNA2 | |
| SCHEMBL5416473 | 0.89 | CCNA2 (0.43) | KDM5ATRPV1PIK3CDMAP4K1CCNA2 | |
| SCHEMBL5410771 | 0.89 | POLB (0.40) | TRPV1MAP4K1 | |
| SCHEMBL5410765 | 0.89 | POLB (0.40) | TRPV1MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199147-B2 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-04-03 | — | — | US | disclosed |
| US-20040138286-A1 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2004-07-15 | — | — | US | disclosed |
| EP-1403255-A1 | Rho KINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138286-A1 | Rho kinase inhibitors | ROCK1, ROCK2, ARHGDIA | KDM5A 2551/4885TRPV1 4181/4885CDK9 693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.