Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CACNB4 | O00305 | 3/20 | 0.43 |
| ▸ | CACNA1A | O00555 | 3/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.43 |
| ▸ | CACNG3 | O60359 | 3/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.43 |
| ▸ | CACNB3 | P54284 | 3/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.43 |
| ▸ | CACNG7 | P62955 | 3/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.43 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.43 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.43 |
| ▸ | CACNG1 | Q06432 | 3/20 | 0.43 |
| ▸ | CACNB2 | Q08289 | 3/20 | 0.43 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.43 |
| ▸ | CACNA1E | Q15878 | 3/20 | 0.43 |
| ▸ | CACNA2D4 | Q7Z3S7 | 3/20 | 0.43 |
| ▸ | CACNA2D3 | Q8IZS8 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9899738 | 0.76 | IDO1 (0.53) | GSK3BALDH1A1 | |
| SCHEMBL524603 | 0.76 | GPR3 (0.50) | CYP1A2MAPK1GPR3HTR2AHDAC3 | |
| SCHEMBL29950614 | 0.76 | GPR3 (0.50) | CYP1A2MAPK1GPR3HTR2AHDAC3 | |
| SCHEMBL5394004 | 0.73 | CACNB4 (0.69) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL11859432 | 0.73 | PARP1 (0.43) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL6903914 | 0.72 | MAPK1 (0.67) | CYP1A2MAPK1NCOR2MEN1CDC25B | |
| SCHEMBL15449470 | 0.72 | MEN1 (0.46) | GSK3BCYP1A2MAPK1NCOR2MEN1 | |
| SCHEMBL12474357 | 0.70 | SMN1; SMN2 (0.52) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL10761977 | 0.68 | CACNB4 (0.36) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL9528121 | 0.68 | CACNB4 (0.36) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7192967-B1 | Cyclic imide-substituted pyridylalkane, alkene, alkine carboxamides useful as cytostatic and immunosuppressive agents | ASTELLAS PHARMA GMBH (DE) | 2007-03-20 | — | — | US | disclosed |
| EP-1042315-B1 | CYCLIC IMIDE-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE CO CHEM PHARM FAB (DE) | 2004-04-14 | — | — | EP | disclosed |
| EP-1042315-A1 | CYCLIC IMIDE-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | Klinge Pharma GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999031087-A1 | CYCLIC IMIDE-SUBSTITUTED PYRIDYLALKANE, ALKENE AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE PHARMA GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |