Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 9/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5405556 | 0.89 | NT5E (0.43) | ALDH1A1TSHRHPGD | |
| SCHEMBL5405683 | 0.89 | KDM4E (0.38) | NPC1RAB9AKMT2AALDH1A1TSHR | |
| SCHEMBL5422355 | 0.88 | ALDH1A1 (0.38) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL5406467 | 0.86 | ALDH1A1 (0.40) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL5402496 | 0.77 | POLB (0.37) | NPC1RAB9AKMT2ACASP3SENP7 | |
| SCHEMBL5405576 | 0.74 | TLR8 (0.38) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL2270872 | 0.66 | KDM4E (0.53) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL5413319 | 0.64 | NT5E (0.44) | ALDH1A1TSHRHPGD | |
| SCHEMBL14504719 | 0.63 | ALDH1A1 (0.59) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL17795038 | 0.63 | BRD4 (0.53) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362049-B1 | PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES | OREAL (FR) | 2006-06-21 | — | — | EP | claimed |
| US-20040088801-A1 | Novel pyrazolo-triazoles and use of said compounds for dyeing keratinous fibres | L'OREAL S.A. (FR) | 2004-05-13 | — | — | US | claimed |
| EP-1362049-A1 | NOVEL PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES | L'OREAL (FR) | 2003-11-19 | — | — | EP | claimed |
| WO-2002064596-A1 | NOVEL PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES | L'OREAL (FR) | 2002-08-22 | — | — | WO | claimed |
| US-7192452-B2 | Pyrazolo-triazoles and use of said compounds for dyeing keratinous fibres | L'OREAL S.A. (FR) | 2007-03-20 | — | — | US | disclosed |
| EP-1362049-B1 | PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES | OREAL (FR) | 2006-06-21 | — | — | EP | disclosed |
| US-20040088801-A1 | Novel pyrazolo-triazoles and use of said compounds for dyeing keratinous fibres | L'OREAL S.A. (FR) | 2004-05-13 | — | — | US | disclosed |
| EP-1362049-A1 | NOVEL PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES | L'OREAL (FR) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002064596-A1 | NOVEL PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES | L'OREAL (FR) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040088801-A1 | Novel pyrazolo-triazoles and use of said compounds for dyeing keratinous fibres | KRT18, CYC1, CBR3 | NPC1 4511/4885RAB9A 4701/4885MEN1 4347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.