Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.38 |
| ▸ | MAT2A | P31153 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5406467 | 0.81 | ALDH1A1 (0.40) | ALDH1A1HPGDKDM4ETSHRHSD17B10 | |
| SCHEMBL5413319 | 0.76 | NT5E (0.44) | NT5EALDH1A1HPGDKDM4ETSHR | |
| SCHEMBL5410150 | 0.74 | NT5E (0.43) | NT5EALDH1A1HPGDKDM4ETSHR | |
| SCHEMBL5402496 | 0.70 | POLB (0.37) | ALDH1A1HPGD | |
| SCHEMBL2270872 | 0.64 | KDM4E (0.53) | ALDH1A1HPGDKDM4ETSHRHSD17B10 | |
| SCHEMBL16331150 | 0.64 | NT5E (0.63) | NT5EKDM4EHSD17B10HSD17B1HSD17B2 | |
| SCHEMBL2267352 | 0.61 | KDM4E (0.53) | ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL1284368 | 0.61 | NT5E (0.62) | NT5EALDH1A1HPGDKDM4ETSHR | |
| SCHEMBL2271082 | 0.60 | TP53 (0.41) | ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL30545101 | 0.60 | ACHE (0.73) | ALDH1A1HSD17B10HSD17B1HSD17B2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362049-B1 | PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES | OREAL (FR) | 2006-06-21 | — | — | EP | claimed |
| US-20040088801-A1 | Novel pyrazolo-triazoles and use of said compounds for dyeing keratinous fibres | L'OREAL S.A. (FR) | 2004-05-13 | — | — | US | claimed |
| EP-1362049-A1 | NOVEL PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES | L'OREAL (FR) | 2003-11-19 | — | — | EP | claimed |
| WO-2002064596-A1 | NOVEL PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES | L'OREAL (FR) | 2002-08-22 | — | — | WO | claimed |
| US-7192452-B2 | Pyrazolo-triazoles and use of said compounds for dyeing keratinous fibres | L'OREAL S.A. (FR) | 2007-03-20 | — | — | US | disclosed |
| EP-1362049-B1 | PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES | OREAL (FR) | 2006-06-21 | — | — | EP | disclosed |
| US-20040088801-A1 | Novel pyrazolo-triazoles and use of said compounds for dyeing keratinous fibres | L'OREAL S.A. (FR) | 2004-05-13 | — | — | US | disclosed |
| EP-1362049-A1 | NOVEL PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES | L'OREAL (FR) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002064596-A1 | NOVEL PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES | L'OREAL (FR) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040088801-A1 | Novel pyrazolo-triazoles and use of said compounds for dyeing keratinous fibres | KRT18, CYC1, CBR3 | NT5E 2509/4885ALDH1A1 180/4885HPGD 696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.