Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ASPH | Q12797 | 1/20 | 0.46 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.46 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5445350 | 0.88 | NPC1 (0.60) | MAPTNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL5402608 | 0.87 | MAPT (0.55) | MAPTNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL597148 | 0.83 | MAPT (0.61) | MAPTNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL3529521 | 0.81 | MAPT (0.56) | MAPTNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL3529524 | 0.81 | MAPT (0.56) | MAPTALDH1A1KMT2AMEN1POLB | |
| SCHEMBL597147 | 0.78 | MAPT (0.52) | MAPTALDH1A1KMT2AMEN1POLB | |
| SCHEMBL10787691 | 0.78 | RAB9A (0.55) | MAPTNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL4947908 | 0.75 | LMNA (0.56) | MAPTNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL11212886 | 0.74 | CA12 (0.52) | MAPTNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL5522100 | 0.72 | MAPT (0.51) | MAPTNPC1RAB9AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7183394-B1 | Peptide nucleic acids with units of hydroxy-amino acids such as serine or threonine, a nucleobase, and an amino acid | GARNER PHILIP P | 2007-02-27 | — | — | US | disclosed |
| WO-2001029086-A1 | PEPTIDES HAVING CORTICOTROPIN RELEASING FACTOR (CRF) ANTAGONIST ACTIVITY | SOLVAY PHARMACEUTICALS B.V. (NL) | 2001-04-26 | — | — | WO | disclosed |
| EP-1094072-A1 | Peptides having corticotropin releasing factor (CRF) antagonist activity | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 2001-04-25 | — | — | EP | disclosed |
| WO-2001014398-A1 | α-HELICAL PEPTIDE NUCLEIC ACID α-PNA | GARNER PHILIP P (US) | 2001-03-01 | — | — | WO | disclosed |