Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18386919 | 0.82 | APP (0.40) | KMT2AMEN1SMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL658219 | 0.82 | CDK4 (0.47) | CDK4CCNE1CDK2SYKPIK3CG | |
| SCHEMBL5388892 | 0.82 | MAPK14 (0.46) | RAB9ANPC1GAAKMT2AMEN1 | |
| SCHEMBL7767558 | 0.82 | CDK4 (0.42) | RAB9ANPC1MAPTNFKB1NFKB2 | |
| SCHEMBL5261001 | 0.79 | CDK4 (0.54) | CDK4CCNE1CDK2SYKPOLB | |
| SCHEMBL15489547 | 0.78 | AURKA (0.51) | MAPTKMT2AMEN1ALDH1A1CDK4 | |
| SCHEMBL16129203 | 0.76 | CDK4 (0.34) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL14940507 | 0.75 | NFKB1 (0.53) | RAB9ANPC1MAPTNFKB1NFKB2 | |
| SCHEMBL7767535 | 0.75 | CDK2 (0.50) | CDK4CCNE1CDK2SYKPIK3CG | |
| SCHEMBL5394104 | 0.74 | EPHB4 (0.45) | RAB9ANPC1MAPTATMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176212-B2 | 2,4-diamino pyrimidine compounds having anti-cell proliferative activity | ASTRAZENECA AB (SE) | 2007-02-13 | — | — | US | disclosed |
| EP-1107957-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2006-10-18 | — | — | EP | disclosed |
| US-20050090493-A1 | 2,4-Diamino pyrimidine compounds having anti-cell proliferative activity | ASTRAZENECA AB | 2005-04-28 | — | — | US | disclosed |
| EP-1107957-A1 | PYRIMIDINE COMPOUNDS | AstraZeneca AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012485-A1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050090493-A1 | 2,4-Diamino pyrimidine compounds having anti-cell proliferative activity | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, H1-3, H1-0 | RAB9A 2735/4885NPC1 2728/4885MAPT 4681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.