Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.50 |
| ▸ | CDK4 | P11802 | 5/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5261001 | 0.95 | CDK4 (0.54) | CDK2CDK4CCNE1GRM4KCNN3 | |
| SCHEMBL5388892 | 0.80 | MAPK14 (0.46) | CDK2CDK4CCNE1MAPK10SYK | |
| SCHEMBL658219 | 0.80 | CDK4 (0.47) | CDK2CDK4CCNE1AURKASYK | |
| SCHEMBL4433403 | 0.77 | MEN1 (0.43) | CDK2CDK4CCNE1APPPIK3CG | |
| SCHEMBL5397901 | 0.76 | CDK2 (0.47) | CDK2CDK4CCNE1AURKAAPP | |
| SCHEMBL5402771 | 0.75 | RAB9A (0.44) | CDK2CDK4CCNE1SYKMAPK14 | |
| SCHEMBL18386919 | 0.75 | APP (0.40) | CDK2CDK4CCNE1APPMAPK10 | |
| SCHEMBL4433335 | 0.75 | RECQL (0.41) | CDK2CDK4CCNE1AURKAGRM5 | |
| SCHEMBL14611819 | 0.75 | CDK4 (0.51) | CDK2CDK4CCNE1GRM4KCNN3 | |
| SCHEMBL12813310 | 0.74 | AURKA (0.61) | CDK2CDK4AURKAMAPK10SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107957-A1 | PYRIMIDINE COMPOUNDS | AstraZeneca AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012485-A1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |