Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4625955 | 0.96 | PDE4B (0.73) | PDE4BPDE4APDE4CPDE4DCSF1R | |
| SCHEMBL4627505 | 0.93 | PDE4B (0.60) | PDE4BMEN1KMT2ACSF1RALDH1A1 | |
| SCHEMBL4627527 | 0.86 | PDE4B (0.62) | PDE4BCSF1RALDH1A1 | |
| SCHEMBL4626888 | 0.84 | PDE4B (0.60) | PDE4BKMT2ACSF1RALDH1A1HTT | |
| SCHEMBL4626932 | 0.84 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DCSF1R | |
| SCHEMBL1275345 | 0.81 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DCSF1R | |
| SCHEMBL4627712 | 0.81 | PDE4B (0.54) | PDE4BMEN1KMT2ACSF1RALDH1A1 | |
| SCHEMBL4627499 | 0.80 | PDE4B (0.74) | PDE4BCSF1RALDH1A1 | |
| SCHEMBL5319163 | 0.79 | PDE4B (0.73) | PDE4BPDE4APDE4CPDE4DCSF1R | |
| SCHEMBL1276135 | 0.79 | PDE4B (0.75) | PDE4BCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007506703-A | — | — | 2007-03-22 | — | — | JP | claimed |
| EP-1673086-A1 | 4-AMINOQUINOLINE-3-CARBOXAMIDE DERIVATIVES AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-06-28 | — | — | EP | claimed |
| WO-2005030212-A1 | 4-AMINOQUINOLINE-3-CARBOXAMIDE DERIVATIVES AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-04-07 | — | — | WO | claimed |