Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.59 |
| ▸ | PDE4A | P27815 | 2/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4628792 | 0.90 | PDE4B (0.57) | PDE4BCSF1RGAAMAPTSYK | |
| SCHEMBL4627712 | 0.88 | PDE4B (0.54) | PDE4BCSF1RGAAMAPT | |
| SCHEMBL4627091 | 0.88 | PDE4B (0.54) | PDE4BCNR1CSF1RGAAMAPT | |
| SCHEMBL4625955 | 0.88 | PDE4B (0.73) | PDE4BPDE4APDE4CPDE4DCNR1 | |
| SCHEMBL4952577 | 0.85 | PDE4B (0.74) | PDE4BPDE4APDE4CPDE4DCSF1R | |
| SCHEMBL5402837 | 0.84 | PDE4B (0.68) | PDE4BPDE4APDE4CPDE4DCNR1 | |
| SCHEMBL4627471 | 0.81 | PDE4B (0.47) | PDE4BCSF1RGAAMAPTSYK | |
| SCHEMBL4627716 | 0.81 | PDE4B (0.60) | PDE4BCSF1RGAAMAPT | |
| SCHEMBL4627633 | 0.80 | SYK (0.49) | PDE4BPDE4APDE4CPDE4DCSF1R | |
| SCHEMBL4628322 | 0.79 | PDE4B (0.57) | PDE4BCSF1RGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673086-B1 | 4-AMINOQUINOLINE-3-CARBOXAMIDE DERIVATIVES AS PDE4 INHIBITORS | GLAXO GROUP LTD (GB) | 2008-01-23 | — | — | EP | claimed |