Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.54 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4628792 | 0.93 | PDE4B (0.57) | PDE4BCSF1RMEN1KMT2AGAA | |
| SCHEMBL4627091 | 0.90 | PDE4B (0.54) | PDE4BENPP2CSF1RGAAMAPT | |
| SCHEMBL4626932 | 0.88 | PDE4B (0.59) | PDE4BCSF1RGAAMAPT | |
| SCHEMBL4627505 | 0.87 | PDE4B (0.60) | PDE4BENPP2CSF1RMEN1KMT2A | |
| SCHEMBL4627716 | 0.86 | PDE4B (0.60) | PDE4BCSF1RALDH1A1GAAMAPT | |
| SCHEMBL4949063 | 0.84 | CSF1R (0.56) | PDE4BCSF1RLMNA | |
| SCHEMBL4627471 | 0.83 | PDE4B (0.47) | PDE4BCSF1RMEN1KMT2AHTT | |
| SCHEMBL4627633 | 0.82 | SYK (0.49) | PDE4BCSF1R | |
| SCHEMBL5402837 | 0.81 | PDE4B (0.68) | PDE4BCSF1RMEN1KMT2AALDH1A1 | |
| SCHEMBL4628322 | 0.81 | PDE4B (0.57) | PDE4BCSF1RGAAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673086-B1 | 4-AMINOQUINOLINE-3-CARBOXAMIDE DERIVATIVES AS PDE4 INHIBITORS | GLAXO GROUP LTD (GB) | 2008-01-23 | — | — | EP | claimed |