Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 7/20 | 0.41 |
| ▸ | CNR1 | P21554 | 6/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | MC5R | P33032 | 1/20 | 0.36 |
| ▸ | MC3R | P41968 | 1/20 | 0.36 |
| ▸ | MC1R | Q01726 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.35 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GPR183 | P32249 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5413805 | 0.85 | MC4R (0.50) | MC4RCNR1CNR2MC5RMC3R | |
| SCHEMBL5418108 | 0.80 | MC4R (0.46) | MC4RCNR2MC5RMC3RMC1R | |
| SCHEMBL5411151 | 0.80 | MC4R (0.45) | MC4RMC5RMC3RMC1R | |
| SCHEMBL5403197 | 0.77 | MC4R (0.54) | MC4RMC5RMC3RMC1R | |
| SCHEMBL5411342 | 0.76 | MC4R (0.49) | MC4RCNR2MC5RMC3RMC1R | |
| SCHEMBL5413876 | 0.76 | MC4R (0.49) | MC4RCNR2MC5RMC3RMC1R | |
| SCHEMBL5410833 | 0.75 | MC4R (0.49) | MC4RCNR2MC5RMC3RMC1R | |
| SCHEMBL5406175 | 0.75 | MC4R (0.51) | MC4RCNR1CNR2MC5RMC3R | |
| SCHEMBL5400390 | 0.74 | MC4R (0.45) | MC4RMC5RMC3RMC1RCACNA2D1 | |
| SCHEMBL5403218 | 0.74 | MC4R (0.49) | MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169777-B2 | Melanocortin receptor agonists | ELI LILLY AND COMPANY (US) | 2007-01-30 | — | — | US | disclosed |