Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | MMP8 | P22894 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ARG1 | P05089 | 1/20 | 0.41 |
| ▸ | ARG2 | P78540 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PPID | Q08752 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5394315 | 0.77 | MEN1 (0.37) | ALDH1A1CYP1A2ARG1ARG2 | |
| SCHEMBL6936802 | 0.75 | ALDH1A1 (0.50) | SMN1; SMN2HIF1AALDH1A1RECQLSLC6A2 | |
| SCHEMBL5948337 | 0.74 | CYP3A4 (0.67) | SMN1; SMN2HIF1AALDH1A1RECQLSLC6A2 | |
| SCHEMBL6936800 | 0.73 | ALDH1A1 (0.49) | SMN1; SMN2HIF1AALDH1A1RECQLSLC6A2 | |
| SCHEMBL14743437 | 0.73 | SMN1; SMN2 (0.60) | SMN1; SMN2HIF1AALDH1A1RECQLSLC6A2 | |
| SCHEMBL9457635 | 0.73 | SMN1; SMN2 (0.60) | SMN1; SMN2HIF1AALDH1A1RECQLSLC6A2 | |
| SCHEMBL2172319 | 0.73 | SMN1; SMN2 (0.60) | SMN1; SMN2HIF1AALDH1A1RECQLSLC6A2 | |
| SCHEMBL4027524 | 0.72 | CYP3A4 (0.53) | SMN1; SMN2HIF1AALDH1A1RECQLSLC6A2 | |
| SCHEMBL5272379 | 0.71 | HIF1A (0.53) | SMN1; SMN2HIF1AALDH1A1RECQLSLC6A2 | |
| SCHEMBL5272375 | 0.71 | HIF1A (0.53) | SMN1; SMN2HIF1AALDH1A1RECQLSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7214715-B2 | Compounds to treat Alzheimer's disease | PHARMACIA & UPJOHN (US) | 2007-05-08 | — | — | US | disclosed |