Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.43 |
| ▸ | HPGD | P15428 | 6/20 | 0.43 |
| ▸ | FASN | P49327 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 7/20 | 0.39 |
| ▸ | GFER | P55789 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5404565 | 1.00 | PTGS1 (0.45) | PTGS1PTGS2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL14434826 | 0.92 | KDM4E (0.44) | PTGS1PTGS2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4152135 | 0.87 | PTGS1 (0.45) | PTGS1PTGS2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4152130 | 0.87 | PTGS1 (0.45) | PTGS1PTGS2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5434896 | 0.83 | RAB9A (0.42) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL5434891 | 0.83 | RAB9A (0.42) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL14370252 | 0.83 | PTGS1 (0.46) | PTGS1PTGS2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4155723 | 0.82 | KDM4E (0.43) | PTGS1PTGS2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4155724 | 0.82 | KDM4E (0.43) | PTGS1PTGS2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5377929 | 0.81 | APOBEC3A (0.35) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007088148-A1 | DERIVATIVES OF THIOPHENE CARBOXILIC ACID AS ANTIVIRAL AGENT | SMITHKLINE BEECHAM CORPORATION (US) | 2007-08-09 | — | — | WO | disclosed |
| WO-2007088148-A1 | DERIVATIVES OF THIOPHENE CARBOXILIC ACID AS ANTIVIRAL AGENT | SMITHKLINE BEECHAM CORPORATION (US) | 2007-08-09 | — | — | WO | disclosed |