Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 10/20 | 0.48 |
| ▸ | CTSL | P07711 | 8/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | HPN | P05981 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | MC3R | P41968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6686849 | 1.00 | CTSS (0.48) | CTSSCTSLEPHX1NPC1RAB9A | |
| SCHEMBL5499131 | 0.86 | CTSS (0.57) | CTSSCTSLCTSK | |
| SCHEMBL6686843 | 0.85 | CTSS (0.45) | CTSSCTSLEPHX1NPC1RAB9A | |
| SCHEMBL6685642 | 0.84 | CTSS (0.54) | CTSSCTSLEPHX1CTSK | |
| SCHEMBL6686917 | 0.84 | CTSS (0.54) | CTSSCTSLEPHX1CTSK | |
| SCHEMBL5844661 | 0.82 | CTSS (0.50) | CTSSCTSLEPHX1NPC1RAB9A | |
| SCHEMBL6693994 | 0.81 | CTSS (0.42) | CTSSCTSLEPHX1NPC1RAB9A | |
| SCHEMBL3017458 | 0.78 | CTSS (0.59) | CTSSCTSLCTSKMC3R | |
| SCHEMBL6685640 | 0.75 | TSHR (0.46) | EPHX1 | |
| SCHEMBL6692653 | 0.74 | CTSS (0.43) | CTSSCTSLEPHX1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658267-A4 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2007-08-01 | — | — | EP | claimed |
| JP-2007502836-A | — | — | 2007-02-15 | — | — | JP | claimed |
| EP-1658267-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2006-05-24 | — | — | EP | claimed |
| WO-2005034848-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2005-04-21 | — | — | WO | claimed |
| EP-1658267-A4 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2007-08-01 | — | — | EP | disclosed |
| EP-1658267-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005034848-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2005-04-21 | — | — | WO | disclosed |