Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049841 | 0.81 | TBXAS1 (0.49) | PDE4BCYP3A4CYP2C19LMNAHTT | |
| SCHEMBL4056450 | 0.80 | PDE4B (0.46) | PDE4BLMNAHTTTBXAS1 | |
| SCHEMBL4052027 | 0.79 | PDE4B (0.54) | PDE4BKDM4EACP1LMNAHTT | |
| SCHEMBL4052155 | 0.78 | PDE4B (0.50) | PDE4BCYP2C19LMNAHTT | |
| SCHEMBL5405067 | 0.75 | ABCG2 (0.41) | PDE4BTBXAS1 | |
| SCHEMBL4052347 | 0.75 | PDE4B (0.44) | PDE4BMAPT | |
| SCHEMBL4051810 | 0.74 | MAPT (0.48) | PDE4BMAPTACP1LMNA | |
| SCHEMBL5750630 | 0.73 | TBXAS1 (0.46) | PDE4BTSHRTBXAS1 | |
| SCHEMBL4059098 | 0.73 | TBXAS1 (0.44) | PDE4BTBXAS1 | |
| SCHEMBL4050499 | 0.73 | PDE4B (0.46) | PDE4BACP1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007510689-A | — | — | 2007-04-26 | — | — | JP | claimed |
| EP-1682519-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2006-07-26 | — | — | EP | claimed |
| WO-2005049581-A1 | PYRIDAZIN-3 (2H) -ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA, S.A. (ES) | 2005-06-02 | — | — | WO | claimed |