Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5750630 | 0.83 | TBXAS1 (0.46) | PDE4BCYP2C9TBXAS1 | |
| SCHEMBL5750305 | 0.82 | ABCG2 (0.52) | ABCG2PDE4BABCB1ABCC1CDK4 | |
| SCHEMBL4049841 | 0.78 | TBXAS1 (0.49) | PDE4BCYP2C9KDRMAPK14TBXAS1 | |
| SCHEMBL4054864 | 0.78 | HTR2C (0.43) | PDE4BTBXAS1 | |
| SCHEMBL4052027 | 0.78 | PDE4B (0.54) | ABCG2PDE4BABCB1ABCC1TBXAS1 | |
| SCHEMBL5405057 | 0.75 | PDE4B (0.39) | PDE4BTBXAS1 | |
| SCHEMBL4049578 | 0.75 | TBXAS1 (0.49) | PDE4BTBXAS1 | |
| SCHEMBL4057455 | 0.75 | ABCG2 (0.52) | ABCG2PDE4BABCC1CDK4CCND1 | |
| SCHEMBL4056450 | 0.74 | PDE4B (0.46) | PDE4BTBXAS1 | |
| SCHEMBL4052278 | 0.74 | PDE4B (0.48) | PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007510689-A | — | — | 2007-04-26 | — | — | JP | claimed |
| EP-1682519-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2006-07-26 | — | — | EP | claimed |
| WO-2005049581-A1 | PYRIDAZIN-3 (2H) -ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA, S.A. (ES) | 2005-06-02 | — | — | WO | claimed |