Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | NAAA | Q02083 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19830587 | 0.98 | LMNA (0.60) | SMN1; SMN2LMNAPOLBL3MBTL1MEN1 | |
| SCHEMBL5935756 | 0.98 | LMNA (0.60) | SMN1; SMN2LMNAPOLBL3MBTL1MEN1 | |
| SCHEMBL10700528 | 0.98 | SMN1; SMN2 (0.60) | SMN1; SMN2LMNAPOLBL3MBTL1MEN1 | |
| SCHEMBL5935769 | 0.96 | LMNA (0.58) | SMN1; SMN2LMNAPOLBL3MBTL1MEN1 | |
| SCHEMBL1859157 | 0.94 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNAPOLBL3MBTL1MEN1 | |
| SCHEMBL7838421 | 0.92 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAPOLBL3MBTL1MEN1 | |
| SCHEMBL1826048 | 0.92 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAPOLBL3MBTL1MEN1 | |
| SCHEMBL11492059 | 0.92 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAPOLBL3MBTL1MEN1 | |
| SCHEMBL6129170 | 0.90 | POLB (0.64) | SMN1; SMN2LMNAPOLBNPSR1NAAA | |
| SCHEMBL3634052 | 0.90 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNAPOLBL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107531674-A | 1-heterocyclyl isochroman compounds and analogs for the treatment of CNS disorders | 赛诺维信制药公司 | 2018-01-02 | — | — | CN | disclosed |
| US-7189756-B2 | Pyrrolidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-6790860-B2 | USEFUL AS INHIBITORS OF METALLOPROTEASES, E.G. ZINC PROTEASES; EFFECTIVE IN TREATING DISEASE STATES ASSOCIATED WITH VASOCONSTRICTION | HOFFMANN-LA ROCHE INC. | 2004-09-14 | — | — | US | disclosed |
| EP-0147909-A1 | Aryloxy-N-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmic activity | A.H. ROBINS COMPANY, INCORPORATED (US) | 1985-07-10 | — | — | EP | disclosed |