⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8074428 | 0.72 | — | — | |
| SCHEMBL974119 | 0.72 | — | — | |
| SCHEMBL13508707 | 0.72 | — | — | |
| SCHEMBL14937953 | 0.69 | MAPT (0.31) | — | |
| SCHEMBL4058540 | 0.67 | THRB (0.30) | — | |
| SCHEMBL25263049 | 0.57 | — | — | |
| SCHEMBL8541328 | 0.56 | — | — | |
| SCHEMBL6393719 | 0.54 | — | — | |
| SCHEMBL3545929 | 0.53 | — | — | |
| SCHEMBL5685461 | 0.51 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7229779-B2 | for drug screening recombinant polypeptides for the treatment of neurodegenerative processes, enzymatic function, affective disorders and immunofunction | ABBOTT LABORATORIES (US) | 2007-06-12 | — | — | US | disclosed |
| US-20040203033-A1 | Variant human alpha7 acetylcholine receptor subunit, and methods of production and use thereof | BRIGGS CLARK A (US) | 2004-10-14 | — | — | US | disclosed |
| US-6683157-B2 | NUCLEOTIDE SEQUENCES CODING POLYPEPTIDE FOR USE IN THE TREATMENT AND DIAGNOSIS OF NERVOUS SYSTEM AND IMMUNOLOGICAL DISORDERS | ABBOTT LABORATORIES | 2004-01-27 | — | — | US | disclosed |
| US-20030073161-A1 | Variant human alpha7 acetylcholine receptor subunit, and methods of production and use thereof | BRIGGS CLARK A (US) | 2003-04-17 | — | — | US | disclosed |
| US-6323000-B2 | TO IDENTIFY COMPOUNDS THAT INTERACT WITH IT | ABBOTT LABORATORIES | 2001-11-27 | — | — | US | disclosed |
| EP-0946726-A2 | A VARIANT HUMAN ALPHA-7 ACETYLCHOLINE RECEPTOR SUBUNIT, AND METHODS OF PRODUCTION AND USE THEREOF | Abbott Laboratories (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028331-A2 | A VARIANT HUMAN ALPHA-7 ACETYLCHOLINE RECEPTOR SUBUNIT, AND METHODS OF PRODUCTION AND USE THEREOF | ABBOTT LABORATORIES (US) | 1998-07-02 | — | — | WO | disclosed |