Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13167764 | 0.89 | SMN1; SMN2 (0.40) | RETKDRAKR1C3MAPTMEN1 | |
| SCHEMBL540359 | 0.87 | KDR (0.46) | RETKDRMAPTBTK | |
| SCHEMBL2815667 | 0.85 | BTK (0.43) | MAPTMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL540802 | 0.78 | MAPT (0.43) | MAPTMEN1CYP1A2CYP3A4KMT2A | |
| SCHEMBL540608 | 0.72 | MAPT (0.49) | RETKDRMAPTMEN1CYP1A2 | |
| SCHEMBL2817428 | 0.71 | TTK (0.42) | MAPTMEN1KMT2A | |
| SCHEMBL20535046 | 0.66 | RPS6KA2 (0.74) | RPS6KA2CA9MAPTKCNK9MEN1 | |
| SCHEMBL540537 | 0.66 | ADORA2A (0.41) | RETKDRMAPTMEN1CYP1A2 | |
| SCHEMBL13130842 | 0.65 | PTGIR (0.43) | MAPTMEN1CYP2C9KMT2A | |
| SCHEMBL29183320 | 0.64 | PDE1B (0.46) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8906928-B2 | Substituted pyrazolo-pyrrolo-pyridine-dione compounds | ARQULE, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8906928-B2 | Substituted pyrazolo-pyrrolo-pyridine-dione compounds | ARQULE, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8906928-B2 | Substituted pyrazolo-pyrrolo-pyridine-dione compounds | ARQULE, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| EP-2414357-A1 | PYRAZOLO-PYRROLOPYRIDINE-DIONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | ArQule, Inc. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114904-A1 | PYRAZOLO-PYRROLOPYRIDINE-DIONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |
| WO-2010114904-A1 | PYRAZOLO-PYRROLOPYRIDINE-DIONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |
| US-20100249120-A1 | SUBSTITUTED PYRAZOLO-PYRROLO-PYRIDINE-DIONE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249120-A1 | SUBSTITUTED PYRAZOLO-PYRROLO-PYRIDINE-DIONE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249120-A1 | SUBSTITUTED PYRAZOLO-PYRROLO-PYRIDINE-DIONE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249120-A1 | SUBSTITUTED PYRAZOLO-PYRROLO-PYRIDINE-DIONE COMPOUNDS | MKI67, TP53, PDK1 | RET 368/4885KDR 1533/4885AKR1C3 1248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.