Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13167764 | 0.90 | SMN1; SMN2 (0.40) | KDRRETMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL540726 | 0.87 | RET (0.45) | KDRRETMAPTBTK | |
| SCHEMBL2815667 | 0.86 | BTK (0.43) | MAPTALDH1A1SMN1; SMN2PARK7BTK | |
| SCHEMBL540802 | 0.78 | MAPT (0.43) | MAPTALDH1A1SMN1; SMN2PARK7 | |
| SCHEMBL540608 | 0.72 | MAPT (0.49) | KDRRETMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL540537 | 0.66 | ADORA2A (0.41) | KDRRETMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7008327 | 0.66 | NR3C1 (0.49) | NR3C1 | |
| SCHEMBL2817428 | 0.65 | TTK (0.42) | MAPTALDH1A1BRD4HPGD | |
| SCHEMBL13904044 | 0.64 | CA1 (0.60) | MAPTALDH1A1SMN1; SMN2KEAP1PARK7 | |
| SCHEMBL6038125 | 0.64 | LMNA (0.55) | ALDH1A1SMN1; SMN2LMNAHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8906928-B2 | Substituted pyrazolo-pyrrolo-pyridine-dione compounds | ARQULE, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8906928-B2 | Substituted pyrazolo-pyrrolo-pyridine-dione compounds | ARQULE, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8906928-B2 | Substituted pyrazolo-pyrrolo-pyridine-dione compounds | ARQULE, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| EP-2414357-A1 | PYRAZOLO-PYRROLOPYRIDINE-DIONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | ArQule, Inc. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114904-A1 | PYRAZOLO-PYRROLOPYRIDINE-DIONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |
| WO-2010114904-A1 | PYRAZOLO-PYRROLOPYRIDINE-DIONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |
| US-20100249120-A1 | SUBSTITUTED PYRAZOLO-PYRROLO-PYRIDINE-DIONE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249120-A1 | SUBSTITUTED PYRAZOLO-PYRROLO-PYRIDINE-DIONE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249120-A1 | SUBSTITUTED PYRAZOLO-PYRROLO-PYRIDINE-DIONE COMPOUNDS | MKI67, TP53, PDK1 | KDR 1533/4885RET 368/4885PPARA 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.