Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.64 |
| ▸ | CCR2 | P41597 | 4/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.60 |
| ▸ | ARHGDIA | P52565 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5641208 | 0.94 | ROCK2 (0.62) | ROCK2ROCK1CCR2CYP3A4 | |
| SCHEMBL5641662 | 0.88 | ROCK2 (0.63) | ROCK2ROCK1CCR2 | |
| SCHEMBL5401638 | 0.84 | ROCK2 (0.63) | ROCK2ROCK1CCR2CYP3A4 | |
| SCHEMBL5643209 | 0.83 | ROCK2 (0.61) | ROCK2ROCK1CCR2CYP3A4ARHGDIA | |
| SCHEMBL5639070 | 0.83 | ROCK2 (0.64) | ROCK2ROCK1CCR2 | |
| SCHEMBL5412716 | 0.83 | ROCK2 (0.62) | ROCK2ROCK1CCR2CYP3A4 | |
| SCHEMBL1717403 | 0.81 | ROCK2 (0.77) | ROCK2ROCK1CCR2CYP3A4ARHGDIA | |
| SCHEMBL31106313 | 0.79 | CCR6 (0.75) | — | |
| SCHEMBL5418331 | 0.78 | ROCK2 (0.71) | ROCK2ROCK1CCR2CYP3A4ARHGDIA | |
| SCHEMBL224917 | 0.78 | ROCK2 (1.00) | ROCK2ROCK1CCR2ARHGDIA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199147-B2 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-04-03 | — | — | US | disclosed |
| US-20040138286-A1 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2004-07-15 | — | — | US | disclosed |
| EP-1403255-A1 | Rho KINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138286-A1 | Rho kinase inhibitors | ROCK1, ROCK2, ARHGDIA | ROCK2 2/4885ROCK1 1/4885CCR2 2824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.