Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.63 |
| ▸ | JAK1 | P23458 | 2/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.59 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.59 |
| ▸ | PAK4 | O96013 | 2/20 | 0.59 |
| ▸ | PIM1 | P11309 | 2/20 | 0.59 |
| ▸ | PRKACA | P17612 | 2/20 | 0.59 |
| ▸ | CDK2 | P24941 | 2/20 | 0.59 |
| ▸ | FLT3 | P36888 | 2/20 | 0.59 |
| ▸ | SYK | P43405 | 2/20 | 0.59 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.59 |
| ▸ | CLK2 | P49760 | 2/20 | 0.59 |
| ▸ | GSK3B | P49841 | 2/20 | 0.59 |
| ▸ | CDK9 | P50750 | 2/20 | 0.59 |
| ▸ | JAK3 | P52333 | 2/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5413116 | 0.87 | JAK3 (0.62) | JAK2JAK1ROCK2ROCK1IRAK4 | |
| SCHEMBL5425226 | 0.87 | ROCK2 (0.74) | JAK2JAK1ROCK2ROCK1IRAK4 | |
| SCHEMBL5415187 | 0.85 | ROCK2 (0.58) | JAK2JAK1ROCK2ROCK1IRAK4 | |
| SCHEMBL5412485 | 0.84 | JAK2 (0.59) | JAK2JAK1ROCK2ROCK1IRAK4 | |
| SCHEMBL5409723 | 0.83 | JAK2 (0.58) | JAK2JAK1ROCK2ROCK1IRAK4 | |
| SCHEMBL5417004 | 0.82 | RPS6KB1 (0.59) | JAK2JAK1ROCK2ROCK1IRAK4 | |
| SCHEMBL5421964 | 0.82 | JAK2 (0.56) | JAK2JAK1ROCK2ROCK1IRAK4 | |
| SCHEMBL5409200 | 0.80 | RPS6KB1 (0.52) | JAK2JAK1ROCK2ROCK1IRAK4 | |
| SCHEMBL5409202 | 0.80 | RPS6KB1 (0.52) | JAK2JAK1ROCK2ROCK1IRAK4 | |
| SCHEMBL5405013 | 0.80 | ROCK2 (0.60) | JAK2JAK1ROCK2ROCK1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199147-B2 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-04-03 | — | — | US | disclosed |
| US-20040138286-A1 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2004-07-15 | — | — | US | disclosed |
| EP-1403255-A1 | Rho KINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138286-A1 | Rho kinase inhibitors | ROCK1, ROCK2, ARHGDIA | JAK2 929/4885JAK1 230/4885ROCK2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.