SCHEMBL5407740

SCHEMBL5407740

CCCNC(=O)c1ccc(S(=O)(=O)NC(=O)c2ccccc2Cl)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FLT1 P17948 14/20 0.64
FLT4 P35916 14/20 0.64
KDR P35968 14/20 0.64
HPGD P15428 1/20 0.54
KDM4E B2RXH2 1/20 0.54
KMT2A Q03164 1/20 0.54
ALDH1A1 P00352 1/20 0.52
LMNA P02545 1/20 0.52
CYP3A4 P08684 1/20 0.52
THRB P10828 1/20 0.52
TSHR P16473 1/20 0.52
NFKB1 P19838 1/20 0.52
HTR2A P28223 1/20 0.52
CYP2C19 P33261 1/20 0.52
ADRA1A P35348 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.49
EGFR P00533 2/20 0.47
USP2 O75604 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13754043 0.86 FLT1 (0.62) FLT1FLT4KDRKDM4EKMT2A
SCHEMBL31249659 0.83 KDM4E (0.52) FLT1FLT4KDRHPGDKDM4E
SCHEMBL3306626 0.80 FLT1 (0.76) FLT1FLT4KDRHPGDKDM4E
SCHEMBL10792384 0.80 HPGD (0.81) HPGDKMT2AALDH1A1THRBTSHR
SCHEMBL3299759 0.79 FLT1 (0.65) FLT1FLT4KDRHPGDKMT2A
SCHEMBL9659192 0.79 FLT1 (0.78) FLT1FLT4KDRKDM4EKMT2A
SCHEMBL31060566 0.79 FLT1 (1.00) FLT1FLT4KDRL3MBTL1EGFR
SCHEMBL11442730 0.78 FLT1 (0.82) FLT1FLT4KDRHPGDKDM4E
SCHEMBL8186817 0.78 EGFR (0.50) HPGDKDM4EKMT2AALDH1A1LMNA
SCHEMBL31249657 0.77 ALDH1A1 (0.50) FLT1FLT4KDRKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7202196-B2 Selective herbicide comprising a tetrazolinone derivative BAYER CROPSCIENCE AG (DE) 2007-04-10 US claimed
US-20050192182-A1 Herbicidal mixtures based on substituted aryl ketones BAYER CROPSCIENCE AG (DE) 2005-09-01 US claimed
US-20050085388-A1 Selective herbicide comprising a tetrazolinone derivative BAYER CROPSCIENCE AG (DE) 2005-04-21 US claimed
EP-1423005-A1 HERBICIDAL MIXTURES BASED ON SUBSTITUTED ARYL KETONES Bayer CropScience AG (DE) 2004-06-02 EP claimed
EP-1423010-A2 SELECTIVE HERBICIDE COMPRISING A TETRAZOLINONE DERIVATIVE Bayer CropScience AG (DE) 2004-06-02 EP claimed
WO-2003020035-A2 SELECTIVE HERBICIDE COMPRISING A TETRAZOLINONE DERIVATIVE BAYER CROPSCIENCE AG (DE) 2003-03-13 WO claimed
WO-2003020033-A1 HERBICIDAL MIXTURES BASED ON SUBSTITUTED ARYL KETONES BAYER CROPSCIENCE AG (DE) 2003-03-13 WO claimed
US-7202196-B2 Selective herbicide comprising a tetrazolinone derivative BAYER CROPSCIENCE AG (DE) 2007-04-10 US disclosed
US-20050192182-A1 Herbicidal mixtures based on substituted aryl ketones BAYER CROPSCIENCE AG (DE) 2005-09-01 US disclosed
US-20050085388-A1 Selective herbicide comprising a tetrazolinone derivative BAYER CROPSCIENCE AG (DE) 2005-04-21 US disclosed
EP-1423005-A1 HERBICIDAL MIXTURES BASED ON SUBSTITUTED ARYL KETONES Bayer CropScience AG (DE) 2004-06-02 EP disclosed
EP-1423010-A2 SELECTIVE HERBICIDE COMPRISING A TETRAZOLINONE DERIVATIVE Bayer CropScience AG (DE) 2004-06-02 EP disclosed
WO-2003020033-A1 HERBICIDAL MIXTURES BASED ON SUBSTITUTED ARYL KETONES BAYER CROPSCIENCE AG (DE) 2003-03-13 WO disclosed
WO-2003020035-A2 SELECTIVE HERBICIDE COMPRISING A TETRAZOLINONE DERIVATIVE BAYER CROPSCIENCE AG (DE) 2003-03-13 WO disclosed
EP-1019368-B1 ACYLSULFAMOYL BENZOIC ACID AMIDES, PLANT PROTECTION AGENTS CONTAINING SAID ACYLSULFAMOYL BENZOIC ACID AMIDES, AND METHOD FOR PRODUCING THE SAME BAYER CROPSCIENCE GMBH (DE) 2003-03-05 EP disclosed
US-6251827-B1 MIXTURE OF PLANT SAFENING AGENT AND ONE OR MORE PESTICIDES HOECHST SCHERING AGREVO GMBH (DE) 2001-06-26 US disclosed
EP-1019368-A1 ACYLSULFAMOYL BENZOIC ACID AMIDES, PLANT PROTECTION AGENTS CONTAINING SAID ACYLSULFAMOYL BENZOIC ACID AMIDES, AND METHOD FOR PRODUCING THE SAME Aventis CropScience GmbH (DE) 2000-07-19 EP disclosed
WO-1999016744-A1 ACYLSULFAMOYL BENZOIC ACID AMIDES, PLANT PROTECTION AGENTS CONTAINING SAID ACYLSULFAMOYL BENZOIC ACID AMIDES, AND METHOD FOR PRODUCING THE SAME AVENTIS CROPSCIENCE GMBH (DE) 1999-04-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050192182-A1 Herbicidal mixtures based on substituted aryl ketones DDT, CBR3, CYP1B1 FLT1 833/4885FLT4 946/4885KDR 968/4885
US-20050085388-A1 Selective herbicide comprising a tetrazolinone derivative DDT, DYRK4, DYRK3 FLT1 3793/4885FLT4 3384/4885KDR 3090/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.