Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.72 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.68 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.68 |
| ▸ | SMYD3 | Q9H7B4 | 5/20 | 0.56 |
| ▸ | MAOB | P27338 | 5/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.50 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.50 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5415165 | 0.95 | MAPK14 (0.67) | MAPK14ROCK2ROCK1SMYD3MAOB | |
| SCHEMBL5415168 | 0.95 | MAPK14 (0.67) | MAPK14ROCK2ROCK1SMYD3MAOB | |
| SCHEMBL5405456 | 0.94 | MAPK14 (0.66) | MAPK14ROCK2ROCK1SMYD3MAOB | |
| SCHEMBL5412477 | 0.94 | MAPK14 (0.66) | MAPK14ROCK2ROCK1SMYD3MAOB | |
| SCHEMBL5415020 | 0.94 | MAPK14 (0.69) | MAPK14ROCK2ROCK1SMYD3MAOB | |
| SCHEMBL5410247 | 0.94 | MAPK14 (0.69) | MAPK14ROCK2ROCK1SMYD3MAOB | |
| SCHEMBL5414865 | 0.93 | MAPK14 (0.65) | MAPK14ROCK2ROCK1SMYD3MAOB | |
| SCHEMBL5418306 | 0.93 | MAPK14 (0.65) | MAPK14ROCK2ROCK1SMYD3MAOB | |
| SCHEMBL5407541 | 0.93 | MAPK14 (0.65) | MAPK14ROCK2ROCK1SMYD3MAOB | |
| SCHEMBL5415905 | 0.92 | MAPK14 (0.64) | MAPK14ROCK2ROCK1SMYD3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106928252-B | A kind of compound and the preparation method and application thereof inhibiting ROCK | 成都先导药物开发股份有限公司 | 2019-09-27 | — | — | CN | disclosed |
| CN-106928252-A | A kind of compound of suppression ROCK and preparation method and application | 成都先导药物开发有限公司 | 2017-07-07 | — | — | CN | disclosed |
| US-7199147-B2 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-04-03 | — | — | US | disclosed |
| US-20040138286-A1 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2004-07-15 | — | — | US | disclosed |
| EP-1403255-A1 | Rho KINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138286-A1 | Rho kinase inhibitors | ROCK1, ROCK2, ARHGDIA | MAPK14 156/4885ROCK2 2/4885ROCK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.