Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.49 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.49 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.49 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.49 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.49 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5408062 | 1.00 | ALDH1A1 (0.57) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL5408048 | 1.00 | ALDH1A1 (0.57) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL5408107 | 0.93 | ALDH1A1 (0.54) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL5408104 | 0.93 | ALDH1A1 (0.54) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL5408102 | 0.93 | ALDH1A1 (0.54) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL5406154 | 0.93 | ALDH1A1 (0.55) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL5406159 | 0.93 | ALDH1A1 (0.55) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL5406147 | 0.93 | ALDH1A1 (0.55) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL5402584 | 0.92 | ALDH1A1 (0.54) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL5402592 | 0.92 | ALDH1A1 (0.54) | ALDH1A1LMNATP53MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7238676-B2 | Purine derivatives | PFIZER INC. (US) | 2007-07-03 | — | — | US | disclosed |
| US-6921753-B2 | Purine derivatives | PFIZER INC (US) | 2005-07-26 | — | — | US | disclosed |
| US-20040229838-A1 | Purine derivatives | PFIZER INC | 2004-11-18 | — | — | US | disclosed |
| EP-1296996-B1 | PURINE DERIVATIVES | PFIZER LTD (GB) | 2004-05-26 | — | — | EP | disclosed |
| EP-1296996-A1 | PURINE DERIVATIVES | Pfizer Limited (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-20020032168-A1 | Purine derivatives | PFIZER INC. | 2002-03-14 | — | — | US | disclosed |
| WO-2002000676-A1 | PURINE DERIVATIVES | PFIZER LIMITED (GB) | 2002-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229838-A1 | Purine derivatives | ADORA2A, ADORA1, ADORA3 | ALDH1A1 226/4885LMNA 2278/4885TP53 3188/4885 |
| US-20020032168-A1 | Purine derivatives | ADORA2A, ADORA1, ADORA3 | ALDH1A1 226/4885LMNA 2278/4885TP53 3188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.