Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | RORA | P35398 | 2/20 | 0.42 |
| ▸ | RORC | P51449 | 2/20 | 0.42 |
| ▸ | RORB | Q92753 | 2/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5406664 | 0.90 | PTGER1 (0.53) | KDM4ETSHRHSD17B10PTGER1CYP1A2 | |
| SCHEMBL4029018 | 0.88 | ESR1 (0.51) | KDM4ETSHRHSD17B10PTGER1MEN1 | |
| SCHEMBL4035483 | 0.84 | ESR1 (0.44) | KDM4EPTGER1MEN1KMT2AMAPT | |
| SCHEMBL5400987 | 0.81 | PTGER1 (0.53) | PTGER1CYP1A2MAPTALDH1A1ESR1 | |
| SCHEMBL5420530 | 0.80 | ALDH1A1 (0.59) | KDM4EPTGER1CYP1A2MAPTALDH1A1 | |
| SCHEMBL4030236 | 0.79 | ESR1 (0.57) | KDM4EPTGER1CYP1A2MEN1KMT2A | |
| SCHEMBL17326571 | 0.77 | MAPT (0.71) | KDM4ETSHRHSD17B10PTGER1CYP1A2 | |
| SCHEMBL594869 | 0.75 | CNR2 (0.52) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4029629 | 0.74 | ESR1 (0.52) | KDM4EPTGER1CYP1A2MEN1KMT2A | |
| SCHEMBL4032078 | 0.74 | ESR1 (0.57) | PTGER1CYP1A2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241791-B2 | Substituted 4-(indazol-3-yl)phenols | WYETH (US) | 2007-07-10 | — | — | US | disclosed |