Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 2/20 | 0.53 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5409012 | 0.90 | KDM4E (0.46) | PTGER1ESR1KDM4ETSHRHSD17B10 | |
| SCHEMBL4030236 | 0.88 | ESR1 (0.57) | PTGER1ESR1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL4029629 | 0.84 | ESR1 (0.52) | PTGER1ESR1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL5418980 | 0.80 | ALDH1A1 (0.63) | PTGER1KDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4029018 | 0.79 | ESR1 (0.51) | PTGER1ESR1KDM4ETSHRHSD17B10 | |
| SCHEMBL15631875 | 0.77 | LMNA (0.69) | PTGER1KDM4ETSHRHSD17B10CYP1A2 | |
| SCHEMBL4035483 | 0.74 | ESR1 (0.44) | PTGER1ESR1KDM4ECYP2C9CYP2C19 | |
| SCHEMBL4035081 | 0.74 | ESR1 (0.57) | PTGER1ESR1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4028897 | 0.74 | ESR1 (0.61) | PTGER1ESR1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL594869 | 0.73 | CNR2 (0.52) | ALDH1A1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241791-B2 | Substituted 4-(indazol-3-yl)phenols | WYETH (US) | 2007-07-10 | — | — | US | disclosed |