Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033183 | 0.88 | ESR1 (0.51) | PTGER1HSD17B10KDM4ETSHRESR1 | |
| SCHEMBL5412777 | 0.83 | KMT2A (0.48) | PTGER1HSD17B10KDM4ETSHRMAPT | |
| SCHEMBL19261470 | 0.83 | MAPT (0.47) | PTGER1HSD17B10KDM4ETSHRMAPT | |
| SCHEMBL4034001 | 0.78 | L3MBTL1 (0.59) | PTGER1KDM4EALDH1A1HTTKMT2A | |
| SCHEMBL4033560 | 0.77 | ESR1 (0.54) | ESR1KMT2APOLB | |
| SCHEMBL15631882 | 0.77 | MAPT (0.75) | PTGER1HSD17B10KDM4ETSHRMAPT | |
| SCHEMBL11843597 | 0.76 | NPSR1 (0.45) | PTGER1HSD17B10KDM4EMAPTALDH1A1 | |
| SCHEMBL5400293 | 0.75 | MAPT (0.50) | HSD17B10KDM4ETSHRMAPTESR1 | |
| SCHEMBL5401020 | 0.74 | ESR1 (0.58) | HSD17B10KDM4ETSHRMAPTESR1 | |
| SCHEMBL4027878 | 0.72 | ESR1 (0.63) | HSD17B10KDM4ETSHRMAPTESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241791-B2 | Substituted 4-(indazol-3-yl)phenols | WYETH (US) | 2007-07-10 | — | — | US | disclosed |