Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.77 |
| ▸ | NPC1 | O15118 | 6/20 | 0.77 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.77 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.77 |
| ▸ | RELA | Q04206 | 3/20 | 0.77 |
| ▸ | GAA | P10253 | 2/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.74 |
| ▸ | TP53 | P04637 | 2/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.74 |
| ▸ | HPGD | P15428 | 2/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | PKM | P14618 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2617338 | 0.87 | ALDH1A1 (1.00) | RAB9AALDH1A1NPC1NFKB1NFKB2 | |
| SCHEMBL2103248 | 0.86 | ALDH1A1 (0.79) | RAB9AALDH1A1NPC1NFKB1NFKB2 | |
| SCHEMBL13325903 | 0.86 | ALDH1A1 (0.94) | RAB9AALDH1A1NPC1NFKB1NFKB2 | |
| SCHEMBL4837433 | 0.85 | ALDH1A1 (1.00) | RAB9AALDH1A1NPC1NFKB1NFKB2 | |
| SCHEMBL4728827 | 0.84 | ALDH1A1 (1.00) | RAB9AALDH1A1NPC1NFKB1NFKB2 | |
| SCHEMBL5420774 | 0.84 | NPC1 (0.77) | RAB9AALDH1A1NPC1NFKB1NFKB2 | |
| SCHEMBL28851904 | 0.84 | RAB9A (1.00) | RAB9AALDH1A1NPC1NFKB1NFKB2 | |
| SCHEMBL972723 | 0.84 | NPC1 (0.77) | RAB9AALDH1A1NPC1NFKB1NFKB2 | |
| SCHEMBL15101540 | 0.84 | RAB9A (0.68) | RAB9AALDH1A1NPC1NFKB1NFKB2 | |
| Bromide SCHEMBL1691886 | 0.83 | NPC1 (0.75) | RAB9AALDH1A1NPC1NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050090523-A1 | 2-(substituted phenyl)imidazo[1,2-a]pyridine compounds; use to treat disorders mediated by the histamine H3 receptor such as sleep disorders, attention deficit hyperactivity disorder, or Alzheimer's disease; 2-[4-[3-(Piperidino)propylamino]phenyl]-8-methylimidazo[1,2-a]pyridine for example | BREITENBUCHER J G (US) | 2005-04-28 | — | — | US | claimed |
| WO-2024219864-A1 | NOVEL COMPOUND EXHIBITING SETDB1 INHIBITORY ACTIVITY, AND USE THEREOF | 주식회사 넷타겟 | 2024-10-24 | — | — | WO | disclosed |
| US-8486936-B2 | Antagonist of smoothened | AllaChem, LLC (US) | 2013-07-16 | — | — | US | disclosed |
| US-8486936-B2 | Antagonist of smoothened | AllaChem, LLC (US) | 2013-07-16 | — | — | US | disclosed |
| US-20110098291-A1 | ANTAGONIST OF SMOOTHENED | Alla Chem Inc. (US) | 2011-04-28 | — | — | US | disclosed |
| US-20110098291-A1 | ANTAGONIST OF SMOOTHENED | Alla Chem Inc. (US) | 2011-04-28 | — | — | US | disclosed |
| WO-2010129620-A1 | IMIDAZO [ 1, 2 -A] PYRIDIN-2 -YL-PHENYL DERIVATIVES TO BE USED IN CANCER TREATMENT | ALLA CHEM, LLC (US) | 2010-11-11 | — | — | WO | disclosed |
| US-7199117-B2 | Phenyl-substituted imidazopyridines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-04-03 | — | — | US | disclosed |
| US-7087757-B2 | Phenyl-substituted imidazopyridines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2006-08-08 | — | — | US | disclosed |
| US-7041827-B2 | Phenyl-substituted imidazopyridines | BREITENBUCHER J GUY | 2006-05-09 | — | — | US | disclosed |
| US-7041828-B2 | Phenyl-substituted imidazopyridines | BREITENBUCHER J GUY | 2006-05-09 | — | — | US | disclosed |
| US-6908929-B2 | Phenyl-substituted imidazopyridines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-06-21 | — | — | US | disclosed |
| US-20050090523-A1 | 2-(substituted phenyl)imidazo[1,2-a]pyridine compounds; use to treat disorders mediated by the histamine H3 receptor such as sleep disorders, attention deficit hyperactivity disorder, or Alzheimer's disease; 2-[4-[3-(Piperidino)propylamino]phenyl]-8-methylimidazo[1,2-a]pyridine for example | BREITENBUCHER J G (US) | 2005-04-28 | — | — | US | disclosed |
| US-20050085502-A1 | Phenyl-substituted imidazopyridines | BREITENBUCHER J G (US) | 2005-04-21 | — | — | US | disclosed |
| US-20050085501-A1 | Phenyl-substituted imidazopyridines | BREITENBUCHER J G (US) | 2005-04-21 | — | — | US | disclosed |
| US-20050049277-A1 | Phenyl-substituted imidazopyridines | BREITENBUCHER J GUY (US) | 2005-03-03 | — | — | US | disclosed |
| US-20050043348-A1 | Phenyl-substituted imidazopyridines | BREITENBUCHER J GUY (US) | 2005-02-24 | — | — | US | disclosed |
| EP-1268478-A2 | PHENYL-SUBSTITUTED IMIDAZOPYRIDINES | Ortho McNeil Pharmaceutical, Inc. (US) | 2003-01-02 | — | — | EP | disclosed |
| US-20020006934-A1 | Phenyl-substituted imidazopyridines | ORTHO MCNEIL PHARMACEUTICAL, INC. | 2002-01-17 | — | — | US | disclosed |
| WO-2001074815-A2 | PHENYL-SUBSTITUTED IMIDAZOPYRIDINES | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2001-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043348-A1 | Phenyl-substituted imidazopyridines | AADAC, DPP4, DPP3 | RAB9A 3610/4885ALDH1A1 767/4885NPC1 323/4885 |
| US-20050085502-A1 | Phenyl-substituted imidazopyridines | AADAC, DPP4, DPP3 | RAB9A 3610/4885ALDH1A1 767/4885NPC1 323/4885 |
| US-20110098291-A1 | ANTAGONIST OF SMOOTHENED | SMO, SHH, GLI1 | RAB9A 1560/4885ALDH1A1 2639/4885NPC1 1407/4885 |
| US-20050085501-A1 | Phenyl-substituted imidazopyridines | AADAC, DPP4, DPP3 | RAB9A 3610/4885ALDH1A1 767/4885NPC1 323/4885 |
| US-20050049277-A1 | Phenyl-substituted imidazopyridines | AADAC, DPP4, DPP3 | RAB9A 3610/4885ALDH1A1 767/4885NPC1 323/4885 |
| US-20050090523-A1 | 2-(substituted phenyl)imidazo[1,2-a]pyridine compounds; use to treat disorders mediated by the histamine H3 receptor such as sleep disorders, attention deficit hyperactivity disorder, or Alzheimer's disease; 2-[4-[3-(Piperidino)propylamino]phenyl]-8-methylimidazo[1,2-a]pyridine for example | HRH3, HRH4, HTR2C | RAB9A 1937/4885ALDH1A1 580/4885NPC1 501/4885 |
| US-20020006934-A1 | Phenyl-substituted imidazopyridines | AADAC, DPP4, DPP3 | RAB9A 3610/4885ALDH1A1 767/4885NPC1 323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.