Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.58 |
| ▸ | MAOB | P27338 | 5/20 | 0.57 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.56 |
| ▸ | WNT3A | P56704 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.49 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5409317 | 0.91 | MAOB (0.57) | ROCK2ROCK1MAOBCTNNB1WNT3A | |
| SCHEMBL5418918 | 0.87 | MAOB (0.58) | ROCK2ROCK1MAOBCTNNB1WNT3A | |
| SCHEMBL5413102 | 0.84 | MAOB (0.71) | ROCK2ROCK1MAOBCTNNB1WNT3A | |
| SCHEMBL5413661 | 0.83 | MAOB (0.56) | ROCK2ROCK1MAOBCTNNB1WNT3A | |
| SCHEMBL5409709 | 0.82 | MAOB (0.71) | ROCK2ROCK1MAOBCTNNB1WNT3A | |
| SCHEMBL5413161 | 0.82 | MAOB (0.67) | ROCK2ROCK1MAOBCTNNB1WNT3A | |
| SCHEMBL6070792 | 0.82 | ROCK2 (0.49) | ROCK2ROCK1MAOBKLKB1MAP4K1 | |
| SCHEMBL5413136 | 0.81 | MAOB (0.67) | ROCK2ROCK1MAOBCTNNB1WNT3A | |
| SCHEMBL5414932 | 0.81 | ROCK2 (0.68) | ROCK2ROCK1MAOBCTNNB1WNT3A | |
| SCHEMBL5441326 | 0.80 | MAOB (0.79) | ROCK2ROCK1MAOBCTNNB1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199147-B2 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-04-03 | — | — | US | disclosed |
| US-20040138286-A1 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2004-07-15 | — | — | US | disclosed |
| EP-1403255-A1 | Rho KINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138286-A1 | Rho kinase inhibitors | ROCK1, ROCK2, ARHGDIA | ROCK2 2/4885ROCK1 1/4885MAOB 2025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.