⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5409266 | 1.00 | — | — | |
| SCHEMBL4591815 | 0.88 | ALDH1A1 (0.35) | — | |
| SCHEMBL10407848 | 0.82 | ALDH1A1 (0.33) | — | |
| SCHEMBL10407850 | 0.82 | ALDH1A1 (0.33) | — | |
| Acrylic Acid Methyl Ester SCHEMBL28834654 | 0.81 | HCAR2 (0.39) | — | |
| SCHEMBL13497222 | 0.80 | — | — | |
| SCHEMBL10536655 | 0.80 | — | — | |
| SCHEMBL19390594 | 0.78 | ALDH1A1 (0.32) | — | |
| SCHEMBL203011 | 0.78 | — | — | |
| SCHEMBL13886584 | 0.78 | ALDH1A1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3168213-B1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2018-08-01 | — | — | EP | disclosed |
| CN-108026321-A | For acrylic acid adhesive and the plasticizer of binder | 道达尔销售服务公司 | 2018-05-11 | — | — | CN | disclosed |
| US-9753034-B2 | Process for the identification of a compound which inhibits the binding of the first bromodomain of each of human BRD-2, BRD-3, and BRD-4 | GLAXOSMITHKLINE LLC (US) | 2017-09-05 | — | — | US | disclosed |
| EP-3168213-A1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | Glaxosmithkline LLC (US) | 2017-05-17 | — | — | EP | disclosed |
| EP-2699551-B1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2016-11-16 | — | — | EP | disclosed |
| US-20160258946-A1 | NOVEL PROCESS | GLAXOSMITHKLINE LLC | 2016-09-08 | — | — | US | disclosed |
| EP-2705032-B1 | DIHYDROQUINOLINE DERIVATIVES AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2016-06-15 | — | — | EP | disclosed |
| US-9360482-B2 | Process for the identification of a compound which inhibits the binding of the second bromodomain of each of human BRD-2, BRD-3, and BRD-4 | GLAXOSMITHKLINE LLC (US) | 2016-06-07 | — | — | US | disclosed |
| US-9315487-B2 | Tetrahydroquinoline derivatives useful as bromodomain inhibitors | GLAXOSMITHKLINE LLC (US) | 2016-04-19 | — | — | US | disclosed |
| EP-2496558-B1 | TETRAHYDROQUINOLINES DERIVATIVES AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2016-03-30 | — | — | EP | disclosed |
| EP-2496945-A1 | NOVEL PROCESS | GlaxoSmithKline LLC (US) | 2012-09-12 | — | — | EP | disclosed |
| EP-2496558-A1 | THETRAHYDROQUINOLINES DERIVATIVES AS BROMODOMAIN INHIBITORS | GlaxoSmithKline LLC (US) | 2012-09-12 | — | — | EP | disclosed |
| EP-2496557-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | GlaxoSmithKline LLC (US) | 2012-09-12 | — | — | EP | disclosed |
| EP-2496235-A1 | BROMODOMAIN INHIBITORS FOR TREATING AUTOIMMUNE AND INFLAMMATORY DISEASES | GlaxoSmithKline LLC (US) | 2012-09-12 | — | — | EP | disclosed |
| US-20120208798-A1 | Tetrahydroquinoline Derivatives And Their Pharmaceutical Use | GLAXOSMITHKLINE LLC | 2012-08-16 | — | — | US | disclosed |
| US-20120208800-A1 | Bromodomain Inhibitors For Treating Autoimmune And Inflammatory Diseases | GLAXOSMITHKLINE LLC | 2012-08-16 | — | — | US | disclosed |
| US-20120208814-A1 | Thetrahydroquinolines Derivatives As Bromodomain Inhibitors | GLAXOSMITHKLINE LLC | 2012-08-16 | — | — | US | disclosed |
| WO-2011054843-A1 | BROMODOMAIN INHIBITORS FOR TREATING AUTOIMMUNE AND INFLAMMATORY DISEASES | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |
| US-7232923-B2 | Method of hydroaminating N-alkenoylcarbamates with primary aromatic amines | IMPERIAL INNOVATIONS LIMITED (GB) | 2007-06-19 | — | — | US | disclosed |
| US-20060183933-A1 | Method of hydroaminating N-alkenoylcarbamates with primary aromatic amines | IMPERIAL COLLEGE INNOVATION LIMITED (GB) | 2006-08-17 | — | — | US | disclosed |