Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.72 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.53 |
| ▸ | PRKACA | P17612 | 2/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.53 |
| ▸ | PRKX | P51817 | 2/20 | 0.53 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.53 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 4/20 | 0.50 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.49 |
| ▸ | WNT3A | P56704 | 3/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5441326 | 0.95 | MAOB (0.79) | MAOBMETTL3MAPK1ROCK2ROCK1 | |
| SCHEMBL5413102 | 0.89 | MAOB (0.71) | MAOBMETTL3MAPK1ROCK2ROCK1 | |
| SCHEMBL5417278 | 0.89 | MAOB (0.71) | MAOBMETTL3MAPK1ROCK2ROCK1 | |
| SCHEMBL5406113 | 0.89 | MAOB (0.71) | MAOBMETTL3MAPK1ROCK2ROCK1 | |
| SCHEMBL5179231 | 0.88 | MAOB (0.70) | MAOBMETTL3MAPK1ROCK2ROCK1 | |
| SCHEMBL5407810 | 0.87 | MAOB (0.69) | MAOBMETTL3MAPK1ROCK2ROCK1 | |
| SCHEMBL5405835 | 0.86 | MAOB (0.68) | MAOBMETTL3MAPK1ROCK2ROCK1 | |
| SCHEMBL5442402 | 0.86 | MAOB (0.74) | MAOBMETTL3MAPK1ROCK2ROCK1 | |
| SCHEMBL5412553 | 0.85 | MAOB (0.67) | MAOBMETTL3MAPK1ROCK2ROCK1 | |
| SCHEMBL5406054 | 0.85 | MAOB (0.67) | MAOBMETTL3EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199147-B2 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-04-03 | — | — | US | disclosed |
| US-20040138286-A1 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2004-07-15 | — | — | US | disclosed |
| EP-1403255-A1 | Rho KINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138286-A1 | Rho kinase inhibitors | ROCK1, ROCK2, ARHGDIA | MAOB 2025/4885METTL3 3310/4885MAPK1 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.