Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 13/20 | 0.64 |
| ▸ | PLK1 | P53350 | 9/20 | 0.64 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.64 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5403798 | 0.86 | PLK1 (0.62) | IKBKEPLK1TBK1 | |
| SCHEMBL5769049 | 0.83 | IKBKE (0.44) | IKBKEPLK1TBK1 | |
| SCHEMBL5402250 | 0.82 | IKBKE (0.41) | IKBKEPLK1TBK1 | |
| SCHEMBL5408899 | 0.82 | IKBKE (0.41) | IKBKEPLK1TBK1 | |
| SCHEMBL5395239 | 0.82 | IKBKE (0.43) | IKBKEPLK1TBK1 | |
| SCHEMBL5394634 | 0.81 | IKBKE (0.45) | IKBKEPLK1TBK1 | |
| SCHEMBL5394828 | 0.81 | IKBKE (0.42) | IKBKEPLK1TBK1 | |
| SCHEMBL5399856 | 0.79 | IKBKE (0.62) | IKBKEPLK1TBK1 | |
| Gsk-319347A SCHEMBL29712606 | 0.78 | IKBKE (1.00) | IKBKEPLK1TBK1 | |
| Gsk-319347A SCHEMBL29493088 | 0.78 | IKBKE (1.00) | IKBKEPLK1TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007522142-A | — | — | 2007-08-09 | — | — | JP | claimed |
| EP-1720864-A1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON IKK3 | GLAXO GROUP LIMITED (GB) | 2006-11-15 | — | — | EP | claimed |
| WO-2005075465-A1 | BENZIMIDAZOL SUBSTITUTED THIOPENE DERIVATIVES WITH ATCTIVITY ON IKK3 | GLAXO GROUP LIMITED (GB) | 2005-08-18 | — | — | WO | claimed |