Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 7/20 | 0.62 |
| ▸ | PLK1 | P53350 | 13/20 | 0.55 |
| ▸ | NEK2 | P51955 | 4/20 | 0.41 |
| ▸ | CSF1R | P07333 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.41 |
| ▸ | STK3 | Q13188 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | BRSK1 | Q8TDC3 | 3/20 | 0.41 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.41 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5403798 | 0.92 | PLK1 (0.62) | IKBKEPLK1NEK2CSF1RKDR | |
| SCHEMBL5410566 | 0.88 | IKBKE (0.66) | IKBKEPLK1NEK2CSF1RKDR | |
| SCHEMBL5409630 | 0.79 | IKBKE (0.64) | IKBKEPLK1TBK1 | |
| SCHEMBL5399351 | 0.77 | IKBKE (0.63) | IKBKEPLK1NEK2KDRPLK3 | |
| SCHEMBL5769049 | 0.77 | IKBKE (0.44) | IKBKEPLK1TBK1 | |
| SCHEMBL5408899 | 0.77 | IKBKE (0.41) | IKBKEPLK1TBK1 | |
| SCHEMBL4034641 | 0.77 | IKBKE (1.00) | IKBKEPLK1NEK2CSF1RKDR | |
| SCHEMBL5395239 | 0.76 | IKBKE (0.43) | IKBKEPLK1TBK1 | |
| SCHEMBL5394634 | 0.76 | IKBKE (0.45) | IKBKEPLK1TBK1 | |
| SCHEMBL5402250 | 0.75 | IKBKE (0.41) | IKBKEPLK1CSF1RTBK1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007522142-A | — | — | 2007-08-09 | — | — | JP | claimed |
| EP-1720864-A1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON IKK3 | GLAXO GROUP LIMITED (GB) | 2006-11-15 | — | — | EP | claimed |
| WO-2005075465-A1 | BENZIMIDAZOL SUBSTITUTED THIOPENE DERIVATIVES WITH ATCTIVITY ON IKK3 | GLAXO GROUP LIMITED (GB) | 2005-08-18 | — | — | WO | claimed |