Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 3/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | SLC16A1 | P53985 | 5/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5411081 | 0.90 | SMN1; SMN2 (0.41) | PDE1APDE1BPDE1CPDE5APDE3B | |
| SCHEMBL5395357 | 0.88 | PDE5A (0.39) | PDE1APDE1BPDE1CPDE5APDE3B | |
| SCHEMBL14370923 | 0.86 | SLC16A1 (0.49) | PDE1APDE1BPDE1CPDE5APDE3B | |
| SCHEMBL5405716 | 0.84 | TP53 (0.44) | PDE1APDE1BPDE1CSLC16A1LMNA | |
| SCHEMBL5404342 | 0.83 | PDE1A (0.38) | PDE1APDE1BPDE1CPDE5APDE3B | |
| SCHEMBL5409602 | 0.83 | PDE1A (0.38) | PDE1APDE1BPDE1CPDE5APDE3B | |
| SCHEMBL5398349 | 0.83 | PDE1A (0.37) | PDE1APDE1BPDE1CPDE5APDE3B | |
| SCHEMBL5415326 | 0.83 | DPP4 (0.39) | PDE1APDE1BPDE1CSLC16A1CYP2C9 | |
| SCHEMBL5400100 | 0.82 | PDE5A (0.38) | PDE1APDE1BPDE1CPDE5APDE3B | |
| SCHEMBL5398848 | 0.82 | PDE1A (0.37) | PDE1APDE1BPDE1CPDE5APDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285558-B2 | Pyrazolo[3,4-d]pyrimidines inhibiting H. pylori infections | ASTRAZENECA AB (SE) | 2007-10-23 | — | — | US | disclosed |
| US-7285558-B2 | Pyrazolo[3,4-d]pyrimidines inhibiting H. pylori infections | ASTRAZENECA AB (SE) | 2007-10-23 | — | — | US | disclosed |
| US-7285558-B2 | Pyrazolo[3,4-d]pyrimidines inhibiting H. pylori infections | ASTRAZENECA AB (SE) | 2007-10-23 | — | — | US | disclosed |