Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.51 |
| ▸ | CCR2 | P41597 | 3/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5409993 | 1.00 | ROCK2 (0.51) | ROCK2ROCK1CCR2CHRM4CYP3A4 | |
| SCHEMBL5418718 | 0.87 | ROCK2 (0.47) | ROCK2ROCK1CCR2CHRM4CYP3A4 | |
| SCHEMBL5418721 | 0.87 | ROCK2 (0.47) | ROCK2ROCK1CCR2CHRM4CYP3A4 | |
| SCHEMBL5418725 | 0.87 | ROCK2 (0.47) | ROCK2ROCK1CCR2CHRM4CYP3A4 | |
| SCHEMBL26132172 | 0.85 | ROCK2 (0.64) | ROCK2ROCK1CCR2CHRM4AXL | |
| SCHEMBL5404525 | 0.85 | ROCK2 (0.53) | ROCK2ROCK1CCR2CHRM4AXL | |
| SCHEMBL5404520 | 0.85 | ROCK2 (0.53) | ROCK2ROCK1CCR2CHRM4AXL | |
| SCHEMBL5419161 | 0.82 | ROCK2 (0.61) | ROCK2ROCK1CCR2CHRM4MEN1 | |
| SCHEMBL5416024 | 0.82 | ROCK2 (0.61) | ROCK2ROCK1CCR2CHRM4AXL | |
| Hydrochloric Acid SCHEMBL5409783 | 0.81 | ROCK2 (0.53) | ROCK2ROCK1CCR2CHRM4AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199147-B2 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-04-03 | — | — | US | disclosed |
| US-20040138286-A1 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2004-07-15 | — | — | US | disclosed |
| EP-1403255-A1 | Rho KINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138286-A1 | Rho kinase inhibitors | ROCK1, ROCK2, ARHGDIA | ROCK2 2/4885ROCK1 1/4885CCR2 2824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.