Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 15/20 | 1.00 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.46 |
| ▸ | NQO1 | P15559 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5416428 | 0.88 | PTPN1 (1.00) | PTPN1EYA3NQO1TTR | |
| SCHEMBL5413786 | 0.84 | PTPN1 (1.00) | PTPN1EYA3NQO1TTR | |
| SCHEMBL5425330 | 0.79 | PTPN1 (1.00) | PTPN1 | |
| SCHEMBL6730825 | 0.78 | PTPN1 (0.93) | PTPN1EYA3TTR | |
| SCHEMBL5764063 | 0.76 | PTPN1 (0.83) | PTPN1EYA3 | |
| SCHEMBL5420762 | 0.75 | PTPN1 (1.00) | PTPN1TTRTHRATHRB | |
| SCHEMBL4461358 | 0.74 | PTPN1 (0.64) | PTPN1EYA3 | |
| SCHEMBL3864688 | 0.74 | PTPN1 (0.71) | PTPN1EYA3TTR | |
| SCHEMBL5416344 | 0.71 | PTPN1 (1.00) | PTPN1 | |
| SCHEMBL4474980 | 0.71 | PTPN1 (0.63) | PTPN1EYA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7291639-B2 | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) | WYETH (US) | 2007-11-06 | — | — | US | claimed |
| US-20030013732-A1 | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) | WYETH (US) | 2003-01-16 | — | — | US | claimed |
| WO-2003000258-A1 | ARYLOXY-ACETIC ACID COMPOUNDS USEFUL AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) | WYETH (US) | 2003-01-03 | — | — | WO | claimed |
| US-6110963-A | FOR PROPHYLAXIS AND TREATMENT OF INSULIN RESISTANCE, HYPERGLYCEMIA, TYPE II DIABETES, MOLULATING GLUCOSE LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-08-29 | — | — | US | claimed |
| US-7291639-B2 | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) | WYETH (US) | 2007-11-06 | — | — | US | disclosed |
| US-20030013732-A1 | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) | WYETH (US) | 2003-01-16 | — | — | US | disclosed |
| WO-2003000258-A1 | ARYLOXY-ACETIC ACID COMPOUNDS USEFUL AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) | WYETH (US) | 2003-01-03 | — | — | WO | disclosed |
| US-6110963-A | FOR PROPHYLAXIS AND TREATMENT OF INSULIN RESISTANCE, HYPERGLYCEMIA, TYPE II DIABETES, MOLULATING GLUCOSE LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013732-A1 | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) | CFH, SERPINH1, APEH | PTPN1 1793/4885EYA3 3669/4885NQO1 683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.