Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 16/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | TACR3 | P29371 | 2/20 | 0.38 |
| ▸ | MLYCD | O95822 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5395813 | 1.00 | TACR1 (0.43) | TACR1ALDH1A1MAPTCES2TACR3 | |
| SCHEMBL4478411 | 0.86 | TACR1 (0.44) | TACR1ALDH1A1MAPTCES2TACR3 | |
| SCHEMBL4478694 | 0.86 | TACR1 (0.44) | TACR1ALDH1A1MAPTCES2TACR3 | |
| SCHEMBL2802418 | 0.84 | TACR1 (0.43) | TACR1ALDH1A1MAPTCES2 | |
| SCHEMBL2181410 | 0.84 | TACR1 (0.43) | TACR1ALDH1A1MAPTCES2 | |
| SCHEMBL24192360 | 0.78 | NPC1 (0.54) | ALDH1A1MAPT | |
| SCHEMBL19281410 | 0.78 | NPC1 (0.54) | ALDH1A1MAPT | |
| SCHEMBL24192005 | 0.78 | NPC1 (0.54) | ALDH1A1MAPT | |
| SCHEMBL5222475 | 0.76 | TAAR1 (0.46) | TACR1ALDH1A1MAPTTACR3 | |
| SCHEMBL2553623 | 0.75 | CTSK (0.41) | ALDH1A1MLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241798-B2 | NK1 antagonists | PFIZER INC. (US) | 2007-07-10 | — | — | US | disclosed |
| US-20050272800-A1 | NK1 antagonists | PFIZER INC | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272800-A1 | NK1 antagonists | TACR1, TACR2, TAC3 | TACR1 1/4885ALDH1A1 2620/4885MAPT 2227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.