Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.64 |
| ▸ | MAOB | P27338 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | NAMPT | P43490 | 2/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.59 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.58 |
| ▸ | CLK2 | P49760 | 1/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.58 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.58 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.58 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.58 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5182382 | 0.87 | NPC1 (0.75) | ROCK2ROCK1MAOBNPC1JAK2 | |
| SCHEMBL5417473 | 0.85 | MAOB (0.67) | ROCK2ROCK1MAOBNPC1JAK2 | |
| SCHEMBL2569111 | 0.85 | NPC1 (0.76) | ROCK2ROCK1MAOBNPC1JAK2 | |
| SCHEMBL5415117 | 0.84 | MAOB (0.80) | ROCK2ROCK1MAOBNPC1JAK2 | |
| SCHEMBL5405791 | 0.81 | MAOB (0.65) | ROCK2ROCK1MAOBNPC1JAK2 | |
| SCHEMBL5415113 | 0.81 | NPC1 (0.82) | ROCK2ROCK1MAOBNPC1JAK2 | |
| SCHEMBL5409621 | 0.80 | MAOB (0.60) | ROCK2ROCK1MAOBNPC1JAK2 | |
| SCHEMBL20284040 | 0.80 | MAOB (0.71) | ROCK2ROCK1MAOBNPC1JAK2 | |
| SCHEMBL5401343 | 0.80 | NPC1 (0.65) | ROCK2ROCK1MAOBNPC1JAK2 | |
| SCHEMBL5381378 | 0.80 | NPC1 (0.76) | ROCK2ROCK1MAOBNPC1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199147-B2 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-04-03 | — | — | US | disclosed |
| US-20040138286-A1 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2004-07-15 | — | — | US | disclosed |
| EP-1403255-A1 | Rho KINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138286-A1 | Rho kinase inhibitors | ROCK1, ROCK2, ARHGDIA | ROCK2 2/4885ROCK1 1/4885MAOB 2025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.