Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5405208 | 0.84 | GSK3B (0.52) | HPGDMEN1KMT2AGSK3BKDR | |
| SCHEMBL5403342 | 0.84 | MAP4K4 (0.53) | HPGDMEN1KMT2AGSK3BKDR | |
| SCHEMBL1784311 | 0.84 | HPGD (0.60) | HPGDMEN1KMT2AGSK3BKDR | |
| SCHEMBL6409156 | 0.84 | HPGD (0.57) | HPGDMEN1KMT2AGSK3BKDR | |
| Gw642138X SCHEMBL5404724 | 0.81 | EGFR (0.57) | GSK3BKDRMAP4K4EGFR | |
| SCHEMBL5399083 | 0.75 | GSK3B (0.55) | HPGDMEN1KMT2AGSK3BKDR | |
| SCHEMBL6417988 | 0.74 | GSK3B (0.57) | HPGDMEN1KMT2AGSK3BKDR | |
| SCHEMBL20742179 | 0.72 | GSK3B (0.52) | HPGDMEN1KMT2AGSK3BKDR | |
| SCHEMBL759984 | 0.71 | HPGD (0.60) | HPGDMEN1KMT2AGSK3BKDR | |
| SCHEMBL5357333 | 0.70 | RAF1 (0.48) | GSK3BKDREGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007513155-A | — | — | 2007-05-24 | — | — | JP | claimed |
| US-20070088031-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2007-04-19 | — | — | US | claimed |
| EP-1689753-A1 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-08-16 | — | — | EP | claimed |
| WO-2005061516-A1 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-07 | — | — | WO | claimed |
| US-20070088031-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2007-04-19 | — | — | US | disclosed |
| US-20070088031-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2007-04-19 | — | — | US | disclosed |
| US-20070088031-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2007-04-19 | — | — | US | disclosed |
| EP-1689753-A1 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005092896-A1 | COMPOUND FOR INHIBITING TYROSINE KINASE ACTIVITY OF DDR2 PROTEIN | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2005-10-06 | — | — | WO | disclosed |
| WO-2005061516-A1 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-07 | — | — | WO | disclosed |
| WO-2005061516-A1 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070088031-A1 | Novel chemical compounds | GSK3B, GSK3A, GSKIP | HPGD 2996/4885MEN1 3096/4885KMT2A 1935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.