Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.57 |
| ▸ | GSK3B | P49841 | 8/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 5/20 | 0.55 |
| ▸ | TEK | Q02763 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5405208 | 0.84 | GSK3B (0.52) | EGFRGSK3BMAP4K4KDR | |
| SCHEMBL6409547 | 0.83 | EGFR (0.57) | EGFRGSK3BKDR | |
| SCHEMBL5403342 | 0.81 | MAP4K4 (0.53) | EGFRGSK3BMAP4K4KDR | |
| SCHEMBL5412486 | 0.81 | HPGD (0.54) | EGFRGSK3BMAP4K4KDR | |
| SCHEMBL1784311 | 0.80 | HPGD (0.60) | EGFRGSK3BMAP4K4KDR | |
| SCHEMBL5450817 | 0.80 | GSK3B (0.60) | EGFRGSK3BKDR | |
| SCHEMBL5655092 | 0.73 | TEK (0.53) | EGFRGSK3BMAP4K4KDRTEK | |
| SCHEMBL5391001 | 0.73 | GSK3B (1.00) | EGFRGSK3BKDR | |
| SCHEMBL15587273 | 0.72 | MAP4K4 (1.00) | MAP4K4 | |
| SCHEMBL8293366 | 0.71 | GSK3B (1.00) | GSK3BKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007513155-A | — | — | 2007-05-24 | — | — | JP | claimed |
| US-20070088031-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2007-04-19 | — | — | US | claimed |
| EP-1689753-A1 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-08-16 | — | — | EP | claimed |
| WO-2005061516-A1 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-07 | — | — | WO | claimed |
| US-20080287466-A1 | 4-AMINO-2,3-DISUBSTITUTED THIENO [2,3,D]PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | ADAMS JERRY LEROY | 2008-11-20 | — | — | US | disclosed |
| US-20080287466-A1 | 4-AMINO-2,3-DISUBSTITUTED THIENO [2,3,D]PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | ADAMS JERRY LEROY | 2008-11-20 | — | — | US | disclosed |
| US-7427623-B2 | 4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof | SMITHKLINE BEECHAM CORPORATION (US) | 2008-09-23 | — | — | US | disclosed |
| US-7427623-B2 | 4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof | SMITHKLINE BEECHAM CORPORATION (US) | 2008-09-23 | — | — | US | disclosed |
| US-20070088031-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2007-04-19 | — | — | US | disclosed |
| US-20070088031-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2007-04-19 | — | — | US | disclosed |
| US-20070088031-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2007-04-19 | — | — | US | disclosed |
| EP-1689753-A1 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005061516-A1 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-07 | — | — | WO | disclosed |
| WO-2005061516-A1 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287466-A1 | 4-AMINO-2,3-DISUBSTITUTED THIENO [2,3,D]PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | TIE1, TEK, KDR | EGFR 47/4885GSK3B 1284/4885MAP4K4 554/4885 |
| US-20070088031-A1 | Novel chemical compounds | GSK3B, GSK3A, GSKIP | EGFR 2349/4885GSK3B 1/4885MAP4K4 236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.