Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.61 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30859372 | 0.81 | KMT2A (0.52) | JAK2CSF1RMEN1KMT2AALDH1A1 | |
| SCHEMBL541066 | 0.79 | MAPT (0.49) | JAK2SMN1; SMN2MEN1USP2KMT2A | |
| SCHEMBL15467001 | 0.76 | HRH3 (0.87) | HRH3SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL28310823 | 0.74 | HRH3 (0.65) | HRH3JAK2SMN1; SMN2MEN1USP2 | |
| SCHEMBL210965 | 0.73 | HRH3 (0.59) | HRH3JAK2MAPKAPK2SMN1; SMN2LRRK2 | |
| 4-(Biphenyl-4-Ylmethyl)Morpholine SCHEMBL1691308 | 0.72 | HRH3 (0.85) | HRH3SMN1; SMN2TSHRALDH1A1MAPT | |
| SCHEMBL27734125 | 0.71 | HRH3 (0.61) | HRH3CHEK1JAK2MAPKAPK2SMN1; SMN2 | |
| SCHEMBL21565733 | 0.71 | HRH3 (0.58) | HRH3JAK2MEN1USP2TSHR | |
| SCHEMBL13984650 | 0.71 | HRH3 (0.56) | HRH3CHEK1JAK2SMN1; SMN2LRRK2 | |
| SCHEMBL29725202 | 0.70 | HRH3 (0.55) | HRH3CHEK1SMN1; SMN2MEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12528801-B2 | Substituted azacyles as TRPM8 modulators | GIVAUDAN SA (CH) | 2026-01-20 | — | — | US | disclosed |
| US-20240132487-A1 | SUBSTITUTED AZACYLES AS TRMP8 MODULATORS | GIVAUDAN SA (CH) | 2024-04-25 | — | — | US | disclosed |
| US-9139557-B2 | Carboxamide compounds and their use as calpain inhibitors | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-09-22 | — | — | US | disclosed |
| EP-2439205-B1 | Carboxamide compounds and their use as calpain inhibitors | ABBVIE DEUTSCHLAND (DE) | 2015-03-11 | — | — | EP | disclosed |
| US-20130245003-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2013-09-19 | — | — | US | disclosed |
| US-8436034-B2 | Carboxamide compounds and their use as calpain inhibitors | ABBOTT GMBH & CO. KG (DE) | 2013-05-07 | — | — | US | disclosed |
| EP-2121653-B1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2012-02-08 | — | — | EP | disclosed |
| US-20100298326-A1 | Carboxamide compounds and their use as calpain inhibitors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2010-11-25 | — | — | US | disclosed |
| US-7799809-B2 | Carboxamide compounds and their use as calpain inhibitors | ABBOTT GMBH & CO. KG (DE) | 2010-09-21 | — | — | US | disclosed |
| US-7728012-B2 | Carboxamide compounds and their use as calpain inhibitors | ABBOTT GMBH & CO. KG (DE) | 2010-06-01 | — | — | US | disclosed |
| EP-2121653-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | Abbott GmbH & Co. KG (DE) | 2009-11-25 | — | — | EP | disclosed |
| US-20080234330-A1 | Carboxamide compounds and their use as calpain inhibitors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2008-09-25 | — | — | US | disclosed |
| US-20080234329-A1 | Carboxamide compounds and their use as calpain inhibitors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2008-09-25 | — | — | US | disclosed |
| WO-2008080969-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298326-A1 | Carboxamide compounds and their use as calpain inhibitors | CAMK2A, CAPN2, CAPN1 | HRH3 2483/4885CHEK1 3478/4885JAK2 3775/4885 |
| US-20080234329-A1 | Carboxamide compounds and their use as calpain inhibitors | CAMK2A, CAPN2, CAPN1 | HRH3 2483/4885CHEK1 3478/4885JAK2 3775/4885 |
| US-20080234330-A1 | Carboxamide compounds and their use as calpain inhibitors | CAMK2A, CAPN2, CAPN1 | HRH3 2483/4885CHEK1 3478/4885JAK2 3775/4885 |
| US-20240132487-A1 | SUBSTITUTED AZACYLES AS TRMP8 MODULATORS | TRPM8, TRPM7, TRPM5 | HRH3 1399/4885CHEK1 856/4885JAK2 4815/4885 |
| US-12528801-B2 | Substituted azacyles as TRPM8 modulators | TRPM8, TRPM7, TRPM4 | HRH3 452/4885CHEK1 649/4885JAK2 4527/4885 |
| US-20130245003-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | CAMK2A, CAPN2, CAPN1 | HRH3 2483/4885CHEK1 3478/4885JAK2 3775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.