Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | ASGR1 | P07306 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3825323 | 1.00 | KDM4E (0.43) | KDM4EALDH1A1LMNAGAAHTT | |
| SCHEMBL5344420 | 1.00 | KDM4E (0.43) | KDM4EALDH1A1LMNAGAAHTT | |
| SCHEMBL6425835 | 0.83 | KDM4E (0.39) | KDM4EALDH1A1LMNAGAAHTT | |
| SCHEMBL22534064 | 0.83 | KDM4E (0.39) | KDM4EALDH1A1LMNAGAAHTT | |
| SCHEMBL9302479 | 0.82 | CCR2 (0.31) | — | |
| SCHEMBL8634789 | 0.77 | CTRB1 (0.35) | — | |
| SCHEMBL553861 | 0.77 | CTRB1 (0.35) | — | |
| SCHEMBL3596240 | 0.77 | CTRB1 (0.35) | — | |
| SCHEMBL10487291 | 0.77 | KDM4E (0.35) | KDM4EALDH1A1LMNAGAAHTT | |
| SCHEMBL10873133 | 0.76 | KDM4E (0.36) | KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090324581-A1 | HETEROARYLAMIDE LOWER CARBOXYLIC ACID DERIVATIVE | DAIICHI SANKYO COMPANY LIMITED (JP) | 2009-12-31 | — | — | US | disclosed |
| US-20090324581-A1 | HETEROARYLAMIDE LOWER CARBOXYLIC ACID DERIVATIVE | DAIICHI SANKYO COMPANY LIMITED (JP) | 2009-12-31 | — | — | US | disclosed |
| EP-2017263-A1 | HETEROARYLAMIDE LOWER CARBOXYLIC ACID DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2009-01-21 | — | — | EP | disclosed |
| US-7309721-B2 | Immunosuppressants for treating diseases and conditions of bone marrow, organ and tissue transplant rejection; chemotherapeutic drug for cancers; antiinflammatory agents for rheumatoid arthritis; activate the production of lymphocyte; 2-Amino-4-(4-(octylphenyl))butanol, O-phosphate | MERCK + CO., INC. (US) | 2007-12-18 | — | — | US | disclosed |
| US-7309721-B2 | Immunosuppressants for treating diseases and conditions of bone marrow, organ and tissue transplant rejection; chemotherapeutic drug for cancers; antiinflammatory agents for rheumatoid arthritis; activate the production of lymphocyte; 2-Amino-4-(4-(octylphenyl))butanol, O-phosphate | MERCK + CO., INC. (US) | 2007-12-18 | — | — | US | disclosed |
| US-20070224263-A1 | Aminoalkylphosphonates and related compounds as Edg receptor agonists | DOHERTY GEORGE A | 2007-09-27 | — | — | US | disclosed |
| US-20070224263-A1 | Aminoalkylphosphonates and related compounds as Edg receptor agonists | DOHERTY GEORGE A | 2007-09-27 | — | — | US | disclosed |
| US-20060089334-A1 | Aminoalkylphosphonates and related compounds as edg receptor agonists | MERCK & CO., INC. | 2006-04-27 | — | — | US | disclosed |
| EP-1482896-A4 | AMINOALKYLPHOSPHONATES AND RELATED COMPOUNDS AS EDG RECEPTOR AGONISTS | MERCK & CO INC (US) | 2005-11-23 | — | — | EP | disclosed |
| US-20050107345-A1 | Aminoalkylphosphonates and related compounds as edg receptor agonists | DOHERTY GEORGE A (US) | 2005-05-19 | — | — | US | disclosed |
| EP-0915830-A1 | BENZOYLPROPIONIC ACID ESTER DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 1999-05-19 | — | — | EP | disclosed |
| WO-1999015494-A1 | 2-AMINOTETRALINES, A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS, FOR THE PREVENTION AND THERAPEUTIC TREATMENT OF INFLAMMATORY AND/OR AUTOIMMUNE PATHOLOGIES | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1999-04-01 | — | — | WO | disclosed |
| EP-0662948-B1 | 2-AMINO-4-PHENYL-4-OXO-BUTYRIC ACID DERIVATIVES WITH KYNURENINASE AND/OR KYNURENINE-3-HYDROXYLASE INHIBITING ACTIVITY | PHARMACIA & UPJOHN SPA (IT) | 1998-10-07 | — | — | EP | disclosed |
| WO-1998006711-A1 | BUTYRIC ACID MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1998-02-19 | — | — | WO | disclosed |
| WO-1998003469-A1 | BENZOYLPROPIONIC ACID ESTER DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-01-29 | — | — | WO | disclosed |
| US-5659037-A | FROM VERATROL DERIVATIVE CHIRAL STARTING MATERIAL USING SERIES OF CHIRAL-PRESERVING REACTIONS | ABBOTT LABORATORIES (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0777655-A1 | PROCESS FOR PREPARING CHIRAL TETRACYCLIC DOPAMINERGIC COMPOUNDS | Abbott Laboratories (US) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996006085-A1 | PROCESS FOR PREPARING CHIRAL TETRACYCLIC DOPAMINERGIC COMPOUNDS | ABBOTT LABORATORIES (US) | 1996-02-29 | — | — | WO | disclosed |
| EP-0662948-A1 | 2-AMINO-4-PHENYL-4-OXO-BUTYRIC ACID DERIVATIVES WITH KYNURENINASE AND/OR KYNURENINE-3-HYDROXYLASE INHIBITING ACTIVITY | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-07-19 | — | — | EP | disclosed |
| WO-1995003271-A1 | 2-AMINO-4-PHENYL-4-OXO-BUTYRIC ACID DERIVATIVES WITH KYNURENINASE AND/OR KYNURENINE-3-HYDROXYLASE INHIBITING ACTIVITY | PHARMACIA S.P.A. (IT) | 1995-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089334-A1 | Aminoalkylphosphonates and related compounds as edg receptor agonists | ADGRF1, EDNRA, ADGRE5 | KDM4E 2778/4885ALDH1A1 1452/4885LMNA 4818/4885 |
| US-20090324581-A1 | HETEROARYLAMIDE LOWER CARBOXYLIC ACID DERIVATIVE | S1PR3, S1PR2, S1PR1 | KDM4E 2795/4885ALDH1A1 1730/4885LMNA 3948/4885 |
| US-20050107345-A1 | Aminoalkylphosphonates and related compounds as edg receptor agonists | EDNRA, ADGRE5, ADGRF1 | KDM4E 2690/4885ALDH1A1 1690/4885LMNA 4827/4885 |
| US-20070224263-A1 | Aminoalkylphosphonates and related compounds as Edg receptor agonists | ADGRE5, EDNRA, ADGRF1 | KDM4E 2800/4885ALDH1A1 1743/4885LMNA 4788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.