Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | EDNRB | P24530 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
| ▸ | ALPG | P10696 | 1/20 | 0.32 |
| ▸ | CCR6 | P51684 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27669692 | 0.66 | TSHR (0.33) | POLBMAPTALDH1A1LMNANPSR1 | |
| Isatin SCHEMBL7073534 | 0.63 | MAPT (0.47) | KMT2AMEN1POLBMAPTALDH1A1 | |
| Isatin SCHEMBL30956357 | 0.62 | MAPT (0.46) | KMT2AMEN1POLBMAPTALDH1A1 | |
| SCHEMBL16150631 | 0.62 | MAPT (0.40) | KMT2AMEN1POLBMAPTALDH1A1 | |
| SCHEMBL6065515 | 0.61 | CES2 (0.37) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL8521194 | 0.60 | KMT2A (0.44) | KMT2AMEN1POLBMAPTALDH1A1 | |
| Bicarbonate SCHEMBL9542773 | 0.60 | NPSR1 (0.39) | KMT2AMEN1POLBMAPTALDH1A1 | |
| SCHEMBL28101622 | 0.59 | MAPT (0.41) | KMT2AMEN1POLBMAPTALDH1A1 | |
| SCHEMBL1137916 | 0.59 | MAPT (0.40) | KMT2AMEN1POLBMAPTALDH1A1 | |
| SCHEMBL8591954 | 0.59 | MAPT (0.46) | KMT2AMAPTALDH1A1LMNAMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271179-B2 | Inhibitors of JAK protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-09-18 | — | — | US | claimed |
| JP-2006513192-A | — | — | 2006-04-20 | — | — | JP | claimed |
| CN-1665808-A | Thiadiazoles or oxadiazoles and their use as inhibitors of JAK protein kinase | VERTEX PHARMA (US) | 2005-09-07 | — | — | CN | claimed |
| EP-1501829-A1 | THIADIAZOLES OR OXADIAZOLES AND THEIR USE AS INHIBITORS OF JAK PROTEIN KINASE | Vertex Pharmaceuticals Incorporated (US) | 2005-02-02 | — | — | EP | claimed |
| WO-2004058753-A1 | THIADIAZOLES OR OXADIAZOLES AND THEIR USE AS INHIBITORS OF JAK PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-07-15 | — | — | WO | claimed |
| US-20040038992-A1 | Inhibitors of Jak protein kinase | VERTEX PHARMACEUTICALS INCORPORATED | 2004-02-26 | — | — | US | claimed |
| US-7271179-B2 | Inhibitors of JAK protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-09-18 | — | — | US | disclosed |
| EP-1501829-A1 | THIADIAZOLES OR OXADIAZOLES AND THEIR USE AS INHIBITORS OF JAK PROTEIN KINASE | Vertex Pharmaceuticals Incorporated (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2004058753-A1 | THIADIAZOLES OR OXADIAZOLES AND THEIR USE AS INHIBITORS OF JAK PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-07-15 | — | — | WO | disclosed |
| US-20040038992-A1 | Inhibitors of Jak protein kinase | VERTEX PHARMACEUTICALS INCORPORATED | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038992-A1 | Inhibitors of Jak protein kinase | JAK2, JAK1, JAK3 | KMT2A 1098/4885MEN1 2739/4885POLB 2847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.