Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MLYCD | O95822 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2219291 | 1.00 | KMT2A (0.47) | KMT2AMEN1NFE2L2CA12CA1 | |
| SCHEMBL16706645 | 0.84 | MEN1 (0.34) | KMT2AMEN1NFE2L2 | |
| SCHEMBL6183911 | 0.83 | CA12 (0.45) | CA12CA1CA2CA7CA9 | |
| SCHEMBL6183914 | 0.83 | CA12 (0.45) | CA12CA1CA2CA7CA9 | |
| SCHEMBL5591568 | 0.81 | TBXAS1 (0.43) | KMT2AMEN1HCAR2KDM4ESMN1; SMN2 | |
| SCHEMBL6570159 | 0.81 | TBXAS1 (0.43) | KMT2AMEN1HCAR2KDM4ESMN1; SMN2 | |
| SCHEMBL9641646 | 0.73 | CYP11B1 (0.54) | KMT2AMEN1KDM4ESMN1; SMN2 | |
| SCHEMBL16903892 | 0.71 | MAPK1 (0.48) | KMT2AMEN1MLYCDALDH1A1CYP1A2 | |
| SCHEMBL21334813 | 0.71 | CYP11B1 (0.56) | — | |
| SCHEMBL1751342 | 0.69 | MAPK1 (0.49) | KMT2AMEN1KDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170049904-A1 | POLYALKYLENE POLYMER COMPOUNDS AND USES THEREOF | BIOGEN MA INC. (US) | 2017-02-23 | — | — | US | disclosed |
| US-20150246097-A9 | Polyalkylene Polymer Compounds and Uses Thereof | BIOGEN IDEC MA INC. (US) | 2015-09-03 | — | — | US | disclosed |
| US-20150132259-A1 | Polyalkylene Polymer Compounds and Uses Thereof | BIOGEN IDEC MA INC. (US) | 2015-05-14 | — | — | US | disclosed |
| US-8524660-B2 | Polyalkylene polymer compounds and uses thereof | BIOGEN IDEC MA INC. (US) | 2013-09-03 | — | — | US | disclosed |
| US-20120014916-A1 | POLYALKYLENE POLYMER COMPOUNDS AND USES THEREOF | BIOGEN MA INC. | 2012-01-19 | — | — | US | disclosed |
| US-8017733-B2 | Covalent attachment of hydrophilic polymers, such as polyalkylene glycol polymers, also known as polyalkylene oxides, to biologically-active molecules | BIOGEN IDEC MA INC. (US) | 2011-09-13 | — | — | US | disclosed |
| US-7179925-B2 | Method for reducing organic compounds in microreactor by means of hydrides and/or the derivatives thereof | MERCK PATENT GMBH (DE) | 2007-02-20 | — | — | US | disclosed |
| US-20040225157-A1 | Method for reducing organic compounds in microreactor by means of hydrides and/or the derivatives thereof | MERCK PATENT GMBH (DE) | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246097-A9 | Polyalkylene Polymer Compounds and Uses Thereof | HAVCR2, TLR3, CCR8 | KMT2A 3367/4885MEN1 4797/4885NFE2L2 4614/4885 |
| US-20170049904-A1 | POLYALKYLENE POLYMER COMPOUNDS AND USES THEREOF | HAVCR2, TLR3, CCR8 | KMT2A 3367/4885MEN1 4797/4885NFE2L2 4614/4885 |
| US-20120014916-A1 | POLYALKYLENE POLYMER COMPOUNDS AND USES THEREOF | HAVCR2, TLR3, CCR8 | KMT2A 3367/4885MEN1 4797/4885NFE2L2 4614/4885 |
| US-20150132259-A1 | Polyalkylene Polymer Compounds and Uses Thereof | HAVCR2, TLR3, CCR8 | KMT2A 3367/4885MEN1 4797/4885NFE2L2 4614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.