SCHEMBL6570159

SCHEMBL6570159

Cn1cncc1C=CC(=O)O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TBXAS1 P24557 5/20 0.43
CYP3A4 P08684 2/20 0.41
KDM4E B2RXH2 1/20 0.41
BLM P54132 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
TSHR P16473 1/20 0.41
ALDH1A1 P00352 2/20 0.39
GAA P10253 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.37
CCNC P24863 1/20 0.36
CDK8 P49336 1/20 0.36
HCAR2 Q8TDS4 2/20 0.35
HDAC3 O15379 1/20 0.35
TNKS O95271 1/20 0.35
HDAC4 P56524 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC7 Q8WUI4 1/20 0.35
HDAC2 Q92769 1/20 0.35
HDAC10 Q969S8 1/20 0.35
HDAC11 Q96DB2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5591568 1.00 TBXAS1 (0.43) TBXAS1CYP3A4KDM4EBLMNPSR1
SCHEMBL2219291 0.81 KMT2A (0.47) KDM4EALDH1A1GAACCNCCDK8
SCHEMBL6183914 0.77 CA12 (0.45) CYP3A4KDM4ECCNCCDK8HCAR2
SCHEMBL1474330 0.74 TBXAS1 (0.45) TBXAS1CYP3A4KDM4EBLMALDH1A1
SCHEMBL1474327 0.74 TBXAS1 (0.45) TBXAS1CYP3A4KDM4EBLMALDH1A1
SCHEMBL18165763 0.73 ALDH1A1 (0.41) TBXAS1KDM4EALDH1A1SMN1; SMN2NPC1
SCHEMBL2219288 0.73 TBXAS1 (0.45) TBXAS1
SCHEMBL7521527 0.73 RAB9A (0.48) TBXAS1KDM4EBLMNPSR1HCAR2
SCHEMBL7521545 0.73 RAB9A (0.48) TBXAS1KDM4EBLMNPSR1HCAR2
SCHEMBL2220247 0.72 IDO1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1404692-A1 ANTIMITOTIC ELEUTHESIDES The University of British Columbia (CA) 2004-04-07 EP disclosed
WO-2003000711-A1 ANTIMITOTIC ELEUTHESIDES THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2003-01-03 WO disclosed
WO-1999029704-A1 A SYNTHETIC PROCESS TOWARD TOTAL SYNTHESIS OF ELEUTHERUBIN AND ITS ANALOGUES AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 1999-06-17 WO disclosed