Morpholine

Morpholine

SCHEMBL5414836

C1COCCN1.CCCCCCCCCCCCCCCCCl

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.54
ALDH1A1 P00352 1/20 0.54
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
KDM4E B2RXH2 1/20 0.44
GAA P10253 1/20 0.44
CYP2C9 P11712 1/20 0.44
TDP1 Q9NUW8 1/20 0.40
GNAI3 P08754 11/20 0.35
GNAO1 P09471 11/20 0.35
GNAI1 P63096 11/20 0.35
THRB P10828 1/20 0.33
EPHX1 P07099 1/20 0.32
FAAH O00519 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Morpholine SCHEMBL11540752 1.00 TSHR (0.54) TSHRALDH1A1MEN1KMT2AKDM4E
Morpholine SCHEMBL8106569 1.00 TSHR (0.54) TSHRALDH1A1MEN1KMT2AKDM4E
Morpholine SCHEMBL27498050 0.98 TSHR (0.50) TSHRALDH1A1MEN1KMT2AKDM4E
Morpholine SCHEMBL7104908 0.91 TSHR (0.45) TSHRALDH1A1MEN1KMT2AKDM4E
Octane SCHEMBL28745870 0.89 MEN1 (0.55) TSHRALDH1A1MEN1KMT2AKDM4E
Nonane SCHEMBL5317273 0.89 MEN1 (0.55) TSHRALDH1A1MEN1KMT2AKDM4E
Tridecane SCHEMBL27548937 0.89 MEN1 (0.55) TSHRALDH1A1MEN1KMT2AKDM4E
Dodecane SCHEMBL28778960 0.89 MEN1 (0.55) TSHRALDH1A1MEN1KMT2AKDM4E
Heptane SCHEMBL28288362 0.89 MEN1 (0.55) TSHRALDH1A1MEN1KMT2AKDM4E
Morpholine SCHEMBL27362751 0.87 MEN1 (0.58) TSHRMEN1KMT2AKDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4015603-B1 METAL-WORKING FLUID COMPOSITIONS AND METHODS FOR MAKING KRATON POLYMERS RES BV (NL) 2024-12-04 EP disclosed
US-11525102-B2 Metal-working fluid compositions and methods for making KRATON POLYMERS LLC (US) 2022-12-13 US disclosed
US-20220195326-A1 Metal-working Fluid Compositions and Methods for Making KRATON POLYMERS LLC (US) 2022-06-23 US disclosed
EP-4015603-A1 METAL-WORKING FLUID COMPOSITIONS AND METHODS FOR MAKING Kraton Polymers Research B.V. (NL) 2022-06-22 EP disclosed
US-9920276-B2 High performance, water-dilutable lubricity additive for multi-metal metalworking applications ETHOX CHEMICALS, LLC (US) 2018-03-20 US disclosed
US-20150225666-A1 HIGH PERFORMANCE, WATER-DILUTABLE LUBRICITY ADDITIVE FOR MULTI-METAL METALWORKING APPLICATIONS FIRST NATIONAL BANK OF PENNSYLVANIA 2015-08-13 US disclosed
WO-2015120418-A1 HIGH PERFORMANCE, WATER-DILUTABLE LUBRICITY ADDITIVE FOR MULTI-METAL METALWORKING APPLICATIONS ETHOX CHEMICALS, LLC (US) 2015-08-13 WO disclosed
US-7180703-B1 Disk drive comprising a spindle motor employing anionic/cationic lubricant to reduce disk surface potential WESTERN DIGITAL TECHNOLOGIES, INC. (US) 2007-02-20 US disclosed
WO-2001042405-A9 WATER SOLUBLE VEGETABLE OIL ESTERS FOR INDUSTRIAL APPLICATIONS CARGILL INC (US) 2002-08-15 WO disclosed
US-6271185-B1 TRANSESTERIFICATION VEGETABLE OIL WITH TRIETHANOLAMINE CARGILL, INCORPORATED 2001-08-07 US disclosed
WO-2001042405-A2 WATER SOLUBLE VEGETABLE OIL ESTERS FOR INDUSTRIAL APPLICATIONS CARGILL INCORPORATED (US) 2001-06-14 WO disclosed
US-4978465-A Sulfurized metalworking lubricants derived from modified natural fats and oils and formulations CINCINNATI-VULCAN COMPANY (US) 1990-12-18 US disclosed
US-4885104-A REACTION PRODUCTS WITH HINDERED POLYOLS AND DICARBOXYLIC ACIDS (OR ESTERS); IMPROVED VISCOSITY CINCINNATI-VULCAN COMPANY (US) 1989-12-05 US disclosed
US-4452710-A AMINE SALTS OF CARBOXYLIC ACID TERMINATED AMIDES CINCINNATI MILACRON INC. (US) 1984-06-05 US disclosed
US-4383937-A Aqueous functional fluid compositions CINCINNATI MILACRON INC. (US) 1983-05-17 US disclosed
US-4379063-A Novel functional fluid CINCINNATI MILACRON INC. (US) 1983-04-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150225666-A1 HIGH PERFORMANCE, WATER-DILUTABLE LUBRICITY ADDITIVE FOR MULTI-METAL METALWORKING APPLICATIONS FDFT1, CDC73, MACF1 TSHR 4659/4885ALDH1A1 1916/4885MEN1 530/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.