Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.52 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MDM4 | O15151 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4893009 | 0.88 | PLA2G2A (0.51) | MAPK8MDM2KMT2AMAPTMDM4 | |
| SCHEMBL4886339 | 0.88 | PLA2G2A (0.55) | MAPK8MDM2KMT2AMAPTMEN1 | |
| SCHEMBL5428229 | 0.85 | AR (0.61) | MAPK8MDM2KMT2AMAPTMEN1 | |
| SCHEMBL5417706 | 0.84 | FEN1 (0.47) | MDM2F2RL3KMT2AMAPTALDH1A1 | |
| SCHEMBL13356428 | 0.82 | AR (0.56) | MAPK8MDM2F2RL3MAPTALDH1A1 | |
| SCHEMBL4887373 | 0.80 | SERPINE1 (0.55) | MAPK8KMT2AMAPTGAALMNA | |
| SCHEMBL6858393 | 0.79 | KMT2A (0.51) | MAPK8KMT2AMAPTF10 | |
| SCHEMBL17625298 | 0.78 | F10 (0.58) | HDAC1HDAC6F2RL3KMT2AMAPT | |
| SCHEMBL5173704 | 0.77 | KMT2A (0.50) | MAPK8MDM2F2RL3KMT2AMAPT | |
| SCHEMBL5172795 | 0.77 | KMT2A (0.50) | MAPK8MDM2KMT2AMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299125-A1 | Substituted indoles | WYETH (US) | 2007-12-27 | — | — | US | disclosed |
| US-7268159-B2 | Substituted indoles | WYETH (US) | 2007-09-11 | — | — | US | disclosed |
| CN-1882537-A | Substituted indolecarboxylic acid derivatives and their use as PAI-1 inhibitors | WYETH CORP (US) | 2006-12-20 | — | — | CN | disclosed |
| EP-1670758-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AND THEIR USE AS PAI-1 INHIBITORS | Wyeth (US) | 2006-06-21 | — | — | EP | disclosed |
| US-20050113438-A1 | Substituted indoles | WYETH (US) | 2005-05-26 | — | — | US | disclosed |
| WO-2005030717-A1 | SUBSTITUTED INDOLE ACID DERIVATIVES AND THEIR USE AS PAI-1 INHIBITORS | WYETH (US) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299125-A1 | Substituted indoles | IDO2, IDO1, INMT | MAPK8 3676/4885MDM2 90/4885HDAC1 1446/4885 |
| US-20050113438-A1 | Substituted indoles | IDO2, IDO1, INMT | MAPK8 3676/4885MDM2 90/4885HDAC1 1446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.