Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.40 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | MAOA | P21397 | 4/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | CALML3 | P27482 | 1/20 | 0.39 |
| ▸ | SDHA | P31040 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL541638 | 0.85 | PDE4B (0.40) | MAOBMAOA | |
| SCHEMBL711710 | 0.83 | GPR119 (0.41) | SCN9AGPR119ALOX5APFEN1USP30 | |
| SCHEMBL541644 | 0.82 | ALOX5AP (0.39) | SCN9AGPR119ALOX5APFEN1CSF1R | |
| SCHEMBL6110542 | 0.78 | GPR119 (0.53) | GPR119MAOBMAOALMNAPTGS1 | |
| SCHEMBL541588 | 0.78 | GRM2 (0.46) | CALML3 | |
| SCHEMBL6111993 | 0.77 | GPR119 (0.46) | GPR119MAOBMAOAUSP30LMNA | |
| SCHEMBL6110625 | 0.77 | GPR119 (0.55) | GPR119MAOBMAOALMNAPTGS1 | |
| SCHEMBL542136 | 0.77 | CALML3 (0.47) | MAOBMAOALMNAPTGS1CALML3 | |
| SCHEMBL17769349 | 0.76 | CALML3 (0.45) | GPR119MAOBMAOALMNAPTGS1 | |
| SCHEMBL17769351 | 0.76 | CALML3 (0.45) | GPR119MAOBMAOALMNAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086968-B1 | 5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-02-08 | — | — | EP | disclosed |
| EP-2086968-A1 | 5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008056335-A1 | 5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-05-15 | — | — | WO | disclosed |