Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.39 |
| ▸ | FEN1 | P39748 | 3/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | LIPE | Q05469 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL541639 | 0.85 | PDE4B (0.39) | RBP4 | |
| SCHEMBL541643 | 0.82 | SCN9A (0.41) | ALOX5APFEN1CSF1RGPR119SCN9A | |
| SCHEMBL541589 | 0.77 | S1PR5 (0.41) | — | |
| SCHEMBL13419698 | 0.75 | GPR119 (0.50) | ALOX5APFEN1CSF1RGPR119SCN9A | |
| SCHEMBL6110542 | 0.74 | GPR119 (0.53) | GPR119 | |
| SCHEMBL15537604 | 0.73 | GPR119 (0.50) | ALOX5APFEN1CSF1RGPR119SCN9A | |
| SCHEMBL3200194 | 0.73 | CALML3 (0.35) | — | |
| SCHEMBL711710 | 0.73 | GPR119 (0.41) | ALOX5APFEN1CSF1RGPR119SCN9A | |
| SCHEMBL6110625 | 0.72 | GPR119 (0.55) | GPR119 | |
| SCHEMBL31330761 | 0.71 | RBP4 (0.58) | ALOX5APFEN1GPR119SCN9ARBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086968-B1 | 5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-02-08 | — | — | EP | disclosed |
| EP-2086968-A1 | 5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008056335-A1 | 5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-05-15 | — | — | WO | disclosed |